5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,1,4-trimethyl-1H-pyrrole-2-carboxamide

Base Information

Chemical Name:5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,1,4-trimethyl-1H-pyrrole-2-carboxamide
CAS No.:1417798-34-5
Molecular Formula:C₂₅H₃₀N₄O₅S
Molecular Weight:498.603
Hs Code.:

Synonyms:5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,1,4-trimethyl-1H-pyrrole-2-carboxamide

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Chemical Property of 5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,1,4-trimethyl-1H-pyrrole-2-carboxamide

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Technology Process of 5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,1,4-trimethyl-1H-pyrrole-2-carboxamide

There total 5 articles about 5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,1,4-trimethyl-1H-pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.9%

: 1417798-32-3
N-methoxy-5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-N,1,4-trimethyl-1H-pyrrole-2-carboxamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1417798-34-5
5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,1,4-trimethyl-1H-pyrrole-2-carboxamide

Guidance literature:: In ethyl acetate; N,N-dimethyl-formamide; at 20 ℃; for 15h; Inert atmosphere;

Reference yield:

: 1417798-26-5
methyl 5-(3-bromo-4-methoxyphenyl)-1,4-dimethyl-1H-pyrrole-2-carboxylate

: 1417798-34-5
5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,1,4-trimethyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / toluene; ethanol / 0.25 h / 25 °C / Inert atmosphere

1.2: 1 h / 95 - 100 °C / Inert atmosphere; Sealed tube

2.1: sodium hydroxide; water / ethanol / 15 h / 0 - 25 °C

2.2: pH 6 - 7

3.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 15 h / 0 - 20 °C

4.1: N,N-dimethyl-formamide; ethyl acetate / 15 h / 20 °C / Inert atmosphere

With water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1417798-41-4
methyl 5-(3-bromo-4-methoxyphenyl)-4-methyl-1H-pyrrole-2-carboxylate

: 1417798-34-5
5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,1,4-trimethyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.75 h / 0 - 20 °C

2.1: potassium carbonate / toluene; ethanol / 0.25 h / 25 °C / Inert atmosphere

2.2: 1 h / 95 - 100 °C / Inert atmosphere; Sealed tube

3.1: sodium hydroxide; water / ethanol / 15 h / 0 - 25 °C

3.2: pH 6 - 7

4.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 15 h / 0 - 20 °C

5.1: N,N-dimethyl-formamide; ethyl acetate / 15 h / 20 °C / Inert atmosphere

With water; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene; paraffin oil;