3-[2-[(4-Chlorophenyl)sulphonylamino]ethyl]-5-(4-methylsulphonylbenzoyl)benzenepropanoic acid

Base Information

Chemical Name:3-[2-[(4-Chlorophenyl)sulphonylamino]ethyl]-5-(4-methylsulphonylbenzoyl)benzenepropanoic acid
CAS No.:161777-89-5
Molecular Formula:C₂₅H₂₄ClNO₇S₂
Molecular Weight:550.053
Hs Code.:

Synonyms:3-[2-[(4-Chlorophenyl)sulphonylamino]ethyl]-5-(4-methylsulphonylbenzoyl)benzenepropanoic acid

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Chemical Property of 3-[2-[(4-Chlorophenyl)sulphonylamino]ethyl]-5-(4-methylsulphonylbenzoyl)benzenepropanoic acid

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Technology Process of 3-[2-[(4-Chlorophenyl)sulphonylamino]ethyl]-5-(4-methylsulphonylbenzoyl)benzenepropanoic acid

There total 9 articles about 3-[2-[(4-Chlorophenyl)sulphonylamino]ethyl]-5-(4-methylsulphonylbenzoyl)benzenepropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 20277-69-4
sodium methansulfinate

: 161777-86-2
3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-(4-fluorobenzoyl)benzenepropanoic acid

: 161777-89-5
3-[2-[(4-Chlorophenyl)sulphonylamino]ethyl]-5-(4-methylsulphonylbenzoyl)benzenepropanoic acid

Guidance literature:: In dimethyl sulfoxide; at 130 ℃;
DOI:10.1016/S0960-894X(98)00242-X

Reference yield:

: 626-39-1
1,3,5-trisbromobenzene

: 161777-89-5
3-[2-[(4-Chlorophenyl)sulphonylamino]ethyl]-5-(4-methylsulphonylbenzoyl)benzenepropanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) n-BuLi / 1.) Et₂O, 2.) Et₂O

2: 89 percent / Pd(OAc)2, P(o-Tol)3, Et₃N / acetonitrile / Heating

3: 99 percent / HCO₂NH₄ / Pd/C / ethanol; tetrahydrofuran

4: 95 percent / (COCl₂)2, DMSO, Et₃N / CH₂Cl₂

5: 50 percent / aq. NaOH / ethanol

6: 1.) (COCl)2, 2.) NH₄OH / 1.) CH₂Cl₂

7: 1.) NaOCl, aq. NaOH / 1.) dioxan, reflux

8: 63 percent / dimethylsulfoxide / 130 °C

With palladium diacetate; ammonium hydroxide; sodium hydroxide; sodium hypochlorite; n-butyllithium; oxalyl dichloride; (COCl₂)2; ammonium formate; dimethyl sulfoxide; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0960-894X(98)00242-X

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 161777-89-5
3-[2-[(4-Chlorophenyl)sulphonylamino]ethyl]-5-(4-methylsulphonylbenzoyl)benzenepropanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) n-BuLi / 1.) Et₂O, 2.) Et₂O

2: 89 percent / Pd(OAc)2, P(o-Tol)3, Et₃N / acetonitrile / Heating

3: 99 percent / HCO₂NH₄ / Pd/C / ethanol; tetrahydrofuran

4: 95 percent / (COCl₂)2, DMSO, Et₃N / CH₂Cl₂

5: 50 percent / aq. NaOH / ethanol

6: 1.) (COCl)2, 2.) NH₄OH / 1.) CH₂Cl₂

7: 1.) NaOCl, aq. NaOH / 1.) dioxan, reflux

8: 63 percent / dimethylsulfoxide / 130 °C

With palladium diacetate; ammonium hydroxide; sodium hydroxide; sodium hypochlorite; n-butyllithium; oxalyl dichloride; (COCl₂)2; ammonium formate; dimethyl sulfoxide; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0960-894X(98)00242-X