3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-1-methyl-2-triethylsilanyloxy-propyl}-6,8-bis-methoxymethoxy-5-methyl-isochroman-1-one

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Chemical Name:3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-1-methyl-2-triethylsilanyloxy-propyl}-6,8-bis-methoxymethoxy-5-methyl-isochroman-1-one
CAS No.:934631-75-1
Molecular Formula:C₅₀H₇₆O₁₁Si₂
Molecular Weight:909.318
Hs Code.:

3-{3-[6-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-1-methyl-2-triethylsilanyloxy-propyl}-6,8-bis-methoxymethoxy-5-methyl-isochroman-1-one

Synonyms:3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-1-methyl-2-triethylsilanyloxy-propyl}-6,8-bis-methoxymethoxy-5-methyl-isochroman-1-one

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Chemical Property of 3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-1-methyl-2-triethylsilanyloxy-propyl}-6,8-bis-methoxymethoxy-5-methyl-isochroman-1-one

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Technology Process of 3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-1-methyl-2-triethylsilanyloxy-propyl}-6,8-bis-methoxymethoxy-5-methyl-isochroman-1-one

There total 12 articles about 3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-1-methyl-2-triethylsilanyloxy-propyl}-6,8-bis-methoxymethoxy-5-methyl-isochroman-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 934631-58-0
4,6-bis-methoxymethoxy-2,3-dimethyl-benzoic acid methyl ester

: 934631-74-0
4-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-2-methyl-3-triethylsilanyloxy-butyraldehyde

: 934631-75-1
3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-1-methyl-2-triethylsilanyloxy-propyl}-6,8-bis-methoxymethoxy-5-methyl-isochroman-1-one

Guidance literature:: 4,6-bis-methoxymethoxy-2,3-dimethyl-benzoic acid methyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

4-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-2-methyl-3-triethylsilanyloxy-butyraldehyde; In tetrahydrofuran; at -100 ℃; for 0.0833333h;
DOI:10.1021/ol063143k

Reference yield:

: 4,6-bis-methoxymethoxy-2,3-dimethyl-benzaldehyde

: 934631-75-1
3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-1-methyl-2-triethylsilanyloxy-propyl}-6,8-bis-methoxymethoxy-5-methyl-isochroman-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH₂PO₄*H₂O; NaClO₂; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O; tetrahydrofuran / 0 °C

2.1: 2.43 g / PPh₃; DIAD / tetrahydrofuran / 0 °C

3.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

3.2: 63 percent / tetrahydrofuran / 0.08 h / -100 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; di-isopropyl azodicarboxylate; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1021/ol063143k

Reference yield:

: 4,6-bis-methoxymethoxy-2,3-dimethyl-benzoic acid

: 934631-75-1
3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-1-methyl-2-triethylsilanyloxy-propyl}-6,8-bis-methoxymethoxy-5-methyl-isochroman-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2.43 g / PPh₃; DIAD / tetrahydrofuran / 0 °C

2.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

2.2: 63 percent / tetrahydrofuran / 0.08 h / -100 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/ol063143k