N-(succinyl-D-Asp(OBn)-2-phenylethylamido)-Trp-2-(2-naphthyl)ethylamide

Base Information

Chemical Name:N-(succinyl-D-Asp(OBn)-2-phenylethylamido)-Trp-2-(2-naphthyl)ethylamide
CAS No.:302911-16-6
Molecular Formula:C₄₆H₄₇N₅O₆
Molecular Weight:765.909
Hs Code.:

Synonyms:N-(succinyl-D-Asp(OBn)-2-phenylethylamido)-Trp-2-(2-naphthyl)ethylamide

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Chemical Property of N-(succinyl-D-Asp(OBn)-2-phenylethylamido)-Trp-2-(2-naphthyl)ethylamide

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Technology Process of N-(succinyl-D-Asp(OBn)-2-phenylethylamido)-Trp-2-(2-naphthyl)ethylamide

There total 8 articles about N-(succinyl-D-Asp(OBn)-2-phenylethylamido)-Trp-2-(2-naphthyl)ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 785024-32-0
(R)-3-Amino-N-phenethyl-succinamic acid benzyl ester

: 302911-15-5
N-succinyl-Trp-2-(2-naphthyl)ethylamide

: 302911-16-6
N-(succinyl-D-Asp(OBn)-2-phenylethylamido)-Trp-2-(2-naphthyl)ethylamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm000937a

Reference yield:

: 2017-68-7
2-(naphthalen-2-yl)ethanamine

: 302911-16-6
N-(succinyl-D-Asp(OBn)-2-phenylethylamido)-Trp-2-(2-naphthyl)ethylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / 1,2-dimethoxy-ethane / 2 h / 20 °C

2: 0.67 h / 20 °C

3: Et₃N; 4-(dimethylamino)pyridine / tetrahydrofuran / 18 h / 20 °C

4: iPr₂NEt; pyBOP / CH₂Cl₂ / 1 h / 20 °C

With dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 1: amidation / 2: acidolysis / 3: Acylation / 4: Acylation;
DOI:10.1021/jm000937a

Reference yield:

: 51186-58-4,98482-77-0
4-benzyl Boc-D-aspartate

: 302911-16-6
N-(succinyl-D-Asp(OBn)-2-phenylethylamido)-Trp-2-(2-naphthyl)ethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / DCCI / CH₂Cl₂ / 64 h / 4 °C

2: TFA / 1 h / 20 °C

3: iPr₂NEt; pyBOP / CH₂Cl₂ / 1 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; 1: Acylation / 2: acidolysis / 3: Acylation;
DOI:10.1021/jm000937a