7-benzyloxy-4-(4-bromo-3,5-dimethoxyphenyl)-3-isocoumarincarboxylic acid

Base Information

• Chemical Name: 7-benzyloxy-4-(4-bromo-3,5-dimethoxyphenyl)-3-isocoumarincarboxylic acid
• CAS No.: 212501-59-2
• Molecular Formula: C₂₅H₁₉BrO₇
• Molecular Weight: 511.326

Synonyms:7-benzyloxy-4-(4-bromo-3,5-dimethoxyphenyl)-3-isocoumarincarboxylic acid

Chemical Property of 7-benzyloxy-4-(4-bromo-3,5-dimethoxyphenyl)-3-isocoumarincarboxylic acid

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Technology Process of 7-benzyloxy-4-(4-bromo-3,5-dimethoxyphenyl)-3-isocoumarincarboxylic acid

There total 2 articles about 7-benzyloxy-4-(4-bromo-3,5-dimethoxyphenyl)-3-isocoumarincarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[5-benzyloxy-2-(4-bromo-3,5-dimethoxy-benzoyl)-benzoyloxy]-malonic acid di-tert-butyl ester → 7-benzyloxy-4-(4-bromo-3,5-dimethoxyphenyl)-3-isocoumarincarboxylic acid (212501-59-2)

Guidance literature:

2-[5-benzyloxy-2-(4-bromo-3,5-dimethoxy-benzoyl)-benzoyloxy]-malonic acid di-tert-butyl ester; With hydrogenchloride; In ethyl acetate; at 20 ℃;

With acetic acid; In 1,4-dioxane; for 6h; Further stages.; Heating;

DOI:10.1021/jm000558h

Reference yield:

3-benzyloxy-6-(4-bromo-3,5-dimethoxybenzoyl)benzoic acid (212501-54-7) → 7-benzyloxy-4-(4-bromo-3,5-dimethoxyphenyl)-3-isocoumarincarboxylic acid (212501-59-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: K₂CO₃ / dimethylformamide / 20 °C

2.1: 4 N HCl / ethyl acetate / 20 °C

2.2: AcOH / dioxane / 6 h / Heating

With hydrogenchloride; potassium carbonate; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm000558h

Reference yield:

7-benzyloxy-4-(4-bromo-3,5-dimethoxyphenyl)-3-isocoumarincarboxylic acid (212501-59-2) → 7-benzyloxy-4-(4-bromo-3,5-dimethoxy-phenyl)-3-hydroxy-1-oxo-isochroman-3-carboxylic acid (212501-65-0)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

DOI:10.1021/jm000558h

upstream raw materials:

3-benzyloxy-6-(4-bromo-3,5-dimethoxybenzoyl)benzoic acid

Downstream raw materials:

7-benzyloxy-4-(4-bromo-3,5-dimethoxy-phenyl)-3-hydroxy-1-oxo-isochroman-3-carboxylic acid

methyl 7-benzyloxy-4-(4-bromo-3,5-dimethoxyphenyl)-2-[(4-tert-butoxycarbonylamino)phenyl]-1,2-dihydro-1-oxo-3-isoquinolinecarboxylate

4-(4-bromo-3,5-dimethoxy-phenyl)-2-(4-tert-butoxycarbonylamino-phenyl)-1-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester

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