7-[3'-azido-2',3'-dideoxy-5'-O-(4-monomethoxytrityl)-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Base Information

Chemical Name:7-[3'-azido-2',3'-dideoxy-5'-O-(4-monomethoxytrityl)-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
CAS No.:915286-84-9
Molecular Formula:C₃₅H₃₅N₇O₅
Molecular Weight:633.707
Hs Code.:

Synonyms:7-[3'-azido-2',3'-dideoxy-5'-O-(4-monomethoxytrityl)-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

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Chemical Property of 7-[3'-azido-2',3'-dideoxy-5'-O-(4-monomethoxytrityl)-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

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Technology Process of 7-[3'-azido-2',3'-dideoxy-5'-O-(4-monomethoxytrityl)-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

There total 10 articles about 7-[3'-azido-2',3'-dideoxy-5'-O-(4-monomethoxytrityl)-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 915286-83-8
7-[3'-azido-5'-O-(4-monomethoxytrityl)-2',3'-dideoxy-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine

: 915286-84-9
7-[3'-azido-2',3'-dideoxy-5'-O-(4-monomethoxytrityl)-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Guidance literature:: With sodium 4-mercaptobenzoate; In N,N-dimethyl-formamide; at 90 ℃; for 1h;
DOI:10.1016/j.bmc.2006.05.074

Reference yield:

: 121150-07-0
7-(2'-deoxy-β-D-erythro-pentofuranosyl)-2-isobutyrylamino-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine

: 915286-84-9
7-[3'-azido-2',3'-dideoxy-5'-O-(4-monomethoxytrityl)-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 4 h / 20 °C

2: 85 percent / ammonia / methanol / 1 h / 20 °C

3: 82 percent / pyridine / 18 h / 20 °C

4: 75 percent / pyridine; 4-dimethylaminopyridine / 16 h / 20 °C

5: 73 percent / lithium azide / dimethylformamide / 2 h / 90 °C

6: 88 percent / sodium thiocresolate / dimethylformamide / 1 h / 90 °C

With pyridine; dmap; lithium azide; sodium 4-mercaptobenzoate; di-isopropyl azodicarboxylate; ammonia; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.05.074

Reference yield:

: 915286-74-7
7-[2'-deoxy-β-D-threo-pentofuranosyl]-2-isobutyrylamino-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine

: 915286-84-9
7-[3'-azido-2',3'-dideoxy-5'-O-(4-monomethoxytrityl)-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / pyridine / 18 h / 20 °C

2: 75 percent / pyridine; 4-dimethylaminopyridine / 16 h / 20 °C

3: 73 percent / lithium azide / dimethylformamide / 2 h / 90 °C

4: 88 percent / sodium thiocresolate / dimethylformamide / 1 h / 90 °C

With pyridine; dmap; lithium azide; sodium 4-mercaptobenzoate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.05.074