2-(9-chloro-7-(3-cyano-4-isopropoxybenzyloxy)-8-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

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Chemical Name:2-(9-chloro-7-(3-cyano-4-isopropoxybenzyloxy)-8-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid
CAS No.:1215118-56-1
Molecular Formula:C₂₅H₂₅ClN₂O₄
Molecular Weight:452.938
Hs Code.:

Synonyms:2-(9-chloro-7-(3-cyano-4-isopropoxybenzyloxy)-8-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

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Chemical Property of 2-(9-chloro-7-(3-cyano-4-isopropoxybenzyloxy)-8-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

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Technology Process of 2-(9-chloro-7-(3-cyano-4-isopropoxybenzyloxy)-8-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

There total 9 articles about 2-(9-chloro-7-(3-cyano-4-isopropoxybenzyloxy)-8-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1215118-55-0
2-(7-(3-cyano-4-isopropoxybenzyloxy)-8-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

: 1215118-56-1
2-(9-chloro-7-(3-cyano-4-isopropoxybenzyloxy)-8-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

Guidance literature:: With N-chloro-succinimide; In dichloromethane; at 0 ℃; for 0.666667h;

Reference yield:

: 50536-53-3
ethyl 5-methoxy-4-methyl-1H-indole-2-carboxylate

: 1215118-56-1
2-(9-chloro-7-(3-cyano-4-isopropoxybenzyloxy)-8-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / toluene; tetrahydrofuran / 0.08 h / 20 °C

1.2: Reflux

1.3: 0.25 h / 180 °C / Microwave irradiation

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

2.2: 2 h / 20 - 60 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 20 °C

4.1: boron tribromide / dichloromethane / 1 h / 0 °C / Inert atmosphere

5.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 65 °C

6.1: water; lithium hydroxide / 1,4-dioxane / 5 h / 20 °C

6.2: pH 3

7.1: N-chloro-succinimide / dichloromethane / 0.67 h / 0 °C

With N-chloro-succinimide; potassium tert-butylate; water; hydrogen; boron tribromide; sodium hydride; caesium carbonate; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1215119-12-2
7-methoxy-8-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-one

: 1215118-56-1
2-(9-chloro-7-(3-cyano-4-isopropoxybenzyloxy)-8-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

1.2: 2 h / 20 - 60 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 20 °C

3.1: boron tribromide / dichloromethane / 1 h / 0 °C / Inert atmosphere

4.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 65 °C

5.1: water; lithium hydroxide / 1,4-dioxane / 5 h / 20 °C

5.2: pH 3

6.1: N-chloro-succinimide / dichloromethane / 0.67 h / 0 °C

With N-chloro-succinimide; water; hydrogen; boron tribromide; sodium hydride; caesium carbonate; lithium hydroxide; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;