2,3-Aziridinedicarboxylicacid,dimethylester,(2R,3R)-(9CI)

Base Information

• Chemical Name: 2,3-Aziridinedicarboxylicacid,dimethylester,(2R,3R)-(9CI)
• CAS No.: 154632-89-0
• Molecular Formula: C₆H₉NO₄
• Molecular Weight: 159.142
• Mol file: 154632-89-0.mol

Synonyms:2,3-Aziridinedicarboxylicacid, dimethyl ester, (2R,3R)- (9CI); 2,3-Aziridinedicarboxylic acid, dimethylester, (R)-

Chemical Property of 2,3-Aziridinedicarboxylicacid,dimethylester,(2R,3R)-(9CI)

Chemical Property:

• PSA: 74.54000
• LogP: -0.99840

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Aziridinedicarboxylicacid,dimethylester,(2R,3R)-(9CI)

There total 3 articles about 2,3-Aziridinedicarboxylicacid,dimethylester,(2R,3R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl aziridine-2,3-dicarboxylate (177473-22-2) → trans-2,3-Dimethoxycarbonyl-aziridin (154632-89-0) + (2S,3S)-Aziridine-2,3-dicarboxylic acid monomethyl ester

Guidance literature:

With sodium chloride; In water; for 24h; Product distribution; Ambient temperature; Candida cylindracea lipase, potassium phosphate buffer (pH 7.5); Candida cyligracea lipase-catalysed hydrolysis of methyl aziridine-2-carboxylates and 2,3-dicarboxylates; enzymatic resolution; conversion, enantioselectivity, enantiomeric excess;

Reference yield:

dimethyl (3S)-2-azido-3-hydroxysuccinate → trans-2,3-Dimethoxycarbonyl-aziridin (154632-89-0)

Guidance literature:

With triphenylphosphine; In N,N-dimethyl-formamide; at 0 - 80 ℃; for 6.5h;

DOI:10.1016/j.tetasy.2003.09.015

Reference yield:

→ trans-2,3-Dimethoxycarbonyl-aziridin (154632-89-0)

Guidance literature:

DOI:10.1055/s-1976-23945

upstream raw materials:

dimethyl aziridine-2,3-dicarboxylate