1-{4-Chloro-3',5'-difluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-yl}pyrrolidin-2-one trifluoroacetate

Base Information

Chemical Name:1-{4-Chloro-3',5'-difluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-yl}pyrrolidin-2-one trifluoroacetate
CAS No.:1382995-55-2
Molecular Formula:C₂HF₃O₂*C₂₄H₂₁ClF₂N₆O
Molecular Weight:596.944
Hs Code.:

Synonyms:1-{4-Chloro-3',5'-difluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-yl}pyrrolidin-2-one trifluoroacetate

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Chemical Property of 1-{4-Chloro-3',5'-difluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-yl}pyrrolidin-2-one trifluoroacetate

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Technology Process of 1-{4-Chloro-3',5'-difluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-yl}pyrrolidin-2-one trifluoroacetate

There total 7 articles about 1-{4-Chloro-3',5'-difluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-yl}pyrrolidin-2-one trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1382995-09-6
1-[6-(1-aminoethyl)-4-chloro-3',5'-difluoro-3-methylbiphenyl-2-yl]pyrrolidin-2-one

: 767-69-1
6-bromopurine

: 76-05-1
trifluoroacetic acid

: 1382995-55-2
1-{4-Chloro-3',5'-difluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-yl}pyrrolidin-2-one trifluoroacetate

Guidance literature:: 1-[6-(1-aminoethyl)-4-chloro-3',5'-difluoro-3-methylbiphenyl-2-yl]pyrrolidin-2-one; 6-bromopurine; With N-ethyl-N,N-diisopropylamine; In ethanol; at 100 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 288401-07-0
1-(5-chloro-2-hydroxy-4-methyl-3-nitrophenyl)ethan-1-one

: 1382995-55-2
1-{4-Chloro-3',5'-difluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-yl}pyrrolidin-2-one trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 0.5 h / -78 - 20 °C

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 2 h / 80 °C / Inert atmosphere

3.1: hydrogenchloride; iron; ammonium chloride / ethanol; water / 1 h / 60 °C

4.1: pyridine / dichloromethane / 1 h / 20 °C

4.2: 2 h / 20 °C

5.1: methanol; ammonium acetate; sodium cyanoborohydride / tetrahydrofuran / 65 °C

6.1: N-ethyl-N,N-diisopropylamine / ethanol / 100 °C

With pyridine; hydrogenchloride; methanol; ammonium acetate; iron; sodium cyanoborohydride; sodium hydrogencarbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;

Reference yield:

: 685892-19-7
1-(5-chloro-2-methoxy-4-methyl-3-nitrophenyl)ethanone

: 1382995-55-2
1-{4-Chloro-3',5'-difluoro-3-methyl-6-[1-(9H-purin-6-ylamino)ethyl]biphenyl-2-yl}pyrrolidin-2-one trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: boron tribromide / dichloromethane / -78 - 0 °C

1.2: 0 °C

2.1: triethylamine / dichloromethane / 0.5 h / -78 - 20 °C

3.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 2 h / 80 °C / Inert atmosphere

4.1: hydrogenchloride; iron; ammonium chloride / ethanol; water / 1 h / 60 °C

5.1: pyridine / dichloromethane / 1 h / 20 °C

5.2: 2 h / 20 °C

6.1: methanol; ammonium acetate; sodium cyanoborohydride / tetrahydrofuran / 65 °C

7.1: N-ethyl-N,N-diisopropylamine / ethanol / 100 °C

With pyridine; hydrogenchloride; methanol; ammonium acetate; boron tribromide; iron; sodium cyanoborohydride; sodium hydrogencarbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;