3'-azido-2',3'-dideoxy-5-[2-(methoxycarbonyl)ethyl]-5'-O-(4-methoxytrityl)uridine

Base Information

Chemical Name:3'-azido-2',3'-dideoxy-5-[2-(methoxycarbonyl)ethyl]-5'-O-(4-methoxytrityl)uridine
CAS No.:279220-30-3
Molecular Formula:C₃₃H₃₃N₅O₇
Molecular Weight:611.654
Hs Code.:

Synonyms:3'-azido-2',3'-dideoxy-5-[2-(methoxycarbonyl)ethyl]-5'-O-(4-methoxytrityl)uridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3'-azido-2',3'-dideoxy-5-[2-(methoxycarbonyl)ethyl]-5'-O-(4-methoxytrityl)uridine

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Technology Process of 3'-azido-2',3'-dideoxy-5-[2-(methoxycarbonyl)ethyl]-5'-O-(4-methoxytrityl)uridine

There total 5 articles about 3'-azido-2',3'-dideoxy-5-[2-(methoxycarbonyl)ethyl]-5'-O-(4-methoxytrityl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2,3'-anhydro-2'-deoxy-5-[2-(methoxycarbonyl)ethyl]-5'-O-(4-methoxytrityl)uridine

: 279220-30-3
3'-azido-2',3'-dideoxy-5-[2-(methoxycarbonyl)ethyl]-5'-O-(4-methoxytrityl)uridine

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 120 ℃; for 20h;
DOI:10.1021/jm991125l

Reference yield:

: 96203-39-3
5-<2-(methoxycarbonyl)ethyl>-2'-deoxyuridine

: 279220-30-3
3'-azido-2',3'-dideoxy-5-[2-(methoxycarbonyl)ethyl]-5'-O-(4-methoxytrityl)uridine

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / pyridine / 20 h

2: pyridine / 22 h / 20 °C

3: DBU / tetrahydrofuran / 5 h / Heating

4: 85 percent / NaN₃ / dimethylformamide / 20 h / 120 °C

With pyridine; sodium azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm991125l

Reference yield:

: 14470-28-1
mono-4-methoxytrityl chloride

: 279220-30-3
3'-azido-2',3'-dideoxy-5-[2-(methoxycarbonyl)ethyl]-5'-O-(4-methoxytrityl)uridine

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / pyridine / 20 h

2: pyridine / 22 h / 20 °C

3: DBU / tetrahydrofuran / 5 h / Heating

4: 85 percent / NaN₃ / dimethylformamide / 20 h / 120 °C

With pyridine; sodium azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm991125l