(E)-methyl 5'-(2-cyano-3-oxo-3-(p-tolyl)prop-1-en-1-yl)-7,7'-dimethoxy-(4,4'-bibenzo[d][1,3]dioxole)-5-carboxylate

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Chemical Name:(E)-methyl 5'-(2-cyano-3-oxo-3-(p-tolyl)prop-1-en-1-yl)-7,7'-dimethoxy-(4,4'-bibenzo[d][1,3]dioxole)-5-carboxylate
CAS No.:1372720-42-7
Molecular Formula:C₂₉H₂₃NO₉
Molecular Weight:529.503
Hs Code.:

Synonyms:(E)-methyl 5'-(2-cyano-3-oxo-3-(p-tolyl)prop-1-en-1-yl)-7,7'-dimethoxy-(4,4'-bibenzo[d][1,3]dioxole)-5-carboxylate

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Chemical Property of (E)-methyl 5'-(2-cyano-3-oxo-3-(p-tolyl)prop-1-en-1-yl)-7,7'-dimethoxy-(4,4'-bibenzo[d][1,3]dioxole)-5-carboxylate

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Technology Process of (E)-methyl 5'-(2-cyano-3-oxo-3-(p-tolyl)prop-1-en-1-yl)-7,7'-dimethoxy-(4,4'-bibenzo[d][1,3]dioxole)-5-carboxylate

There total 7 articles about (E)-methyl 5'-(2-cyano-3-oxo-3-(p-tolyl)prop-1-en-1-yl)-7,7'-dimethoxy-(4,4'-bibenzo[d][1,3]dioxole)-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1372720-31-4
methyl 5'-formyl-7,7'-dimethoxy-(4,4'-bibenzo[d][1,3]dioxole)-5-carboxylate

: 7391-28-8
p-tolueneacetonitrile

: 1372720-42-7
(E)-methyl 5'-(2-cyano-3-oxo-3-(p-tolyl)prop-1-en-1-yl)-7,7'-dimethoxy-(4,4'-bibenzo[d][1,3]dioxole)-5-carboxylate

Guidance literature:: With L-proline; In ethanol; at 20 ℃; for 10h;
DOI:10.1016/j.bmc.2012.02.050

Reference yield:

: 118159-48-1
bicyclol

: 1372720-42-7
(E)-methyl 5'-(2-cyano-3-oxo-3-(p-tolyl)prop-1-en-1-yl)-7,7'-dimethoxy-(4,4'-bibenzo[d][1,3]dioxole)-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium chlorochromate / dichloromethane / 1 h / 0 - 20 °C

2: L-proline / ethanol / 10 h / 20 °C

With pyridinium chlorochromate; L-proline; In ethanol; dichloromethane; 2: Aldol condensation;
DOI:10.1016/j.bmc.2012.02.050

Reference yield:

: 4,4'-dimethoxy-5,6,5',6'-bis(methylenedioxy)-2,2'-biphenyldiformic anhydride

: 1372720-42-7
(E)-methyl 5'-(2-cyano-3-oxo-3-(p-tolyl)prop-1-en-1-yl)-7,7'-dimethoxy-(4,4'-bibenzo[d][1,3]dioxole)-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 3 h / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

3: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 20 °C

4: pyridinium chlorochromate / dichloromethane / 1 h / 0 - 20 °C

5: L-proline / ethanol / 10 h / 20 °C

With dmap; sodium tetrahydroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridinium chlorochromate; L-proline; In tetrahydrofuran; ethanol; dichloromethane; 5: Aldol condensation;
DOI:10.1016/j.bmc.2012.02.050