1R-[4-(4-benzyl-2R,6S-dimethyl-piperazin-1-yl)pyrimidin-2-yl]ethyl butyrate

Base Information

• Chemical Name: 1R-[4-(4-benzyl-2R,6S-dimethyl-piperazin-1-yl)pyrimidin-2-yl]ethyl butyrate
• CAS No.: 300553-64-4
• Molecular Formula: C₂₃H₃₂N₄O₂
• Molecular Weight: 396.533
• Mol file: 300553-64-4.mol

Synonyms:1R-[4-(4-benzyl-2R,6S-dimethyl-piperazin-1-yl)pyrimidin-2-yl]ethyl butyrate

Chemical Property of 1R-[4-(4-benzyl-2R,6S-dimethyl-piperazin-1-yl)pyrimidin-2-yl]ethyl butyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1R-[4-(4-benzyl-2R,6S-dimethyl-piperazin-1-yl)pyrimidin-2-yl]ethyl butyrate

There total 3 articles about 1R-[4-(4-benzyl-2R,6S-dimethyl-piperazin-1-yl)pyrimidin-2-yl]ethyl butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

(3R,5S)-1-benzyl-3,5-dimethylpiperazine (55115-99-6,475486-87-4) + (R)-1-(4-chloro-pyrimidin-2-yl)-ethyl butyrate (300553-69-9) → 1R-[4-(4-benzyl-2R,6S-dimethyl-piperazin-1-yl)pyrimidin-2-yl]ethyl butyrate (300553-64-4)

Guidance literature:

at 150 - 155 ℃; for 24h;

DOI:10.1021/jm010440g

Reference yield:

(R)-1-(4-hydroxypyrimidin-2-yl)ethyl butyrate (300553-75-7) → 1R-[4-(4-benzyl-2R,6S-dimethyl-piperazin-1-yl)pyrimidin-2-yl]ethyl butyrate (300553-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0 - 10 °C

2: 109 g / acetonitrile / 15 h / Heating

With triethylamine; In dichloromethane; acetonitrile;

DOI:10.1021/jm010440g

Reference yield:

(3R,5S)-1-benzyl-3,5-dimethylpiperazine (55115-99-6,475486-87-4) + (R)-1-(4-trifluoromethanesulfonyloxy-pyrimidin-2-yl)-ethyl butyrate (300553-71-3) → 1R-[4-(4-benzyl-2R,6S-dimethyl-piperazin-1-yl)pyrimidin-2-yl]ethyl butyrate (300553-64-4) + Butyric acid (S)-1-[4-((2S,6R)-4-benzyl-2,6-dimethyl-piperazin-1-yl)-pyrimidin-2-yl]-ethyl ester (300553-65-5)

Guidance literature:

In acetonitrile; Heating;

DOI:10.1016/S0960-894X(02)00208-1

upstream raw materials:

(3R,5S)-1-benzyl-3,5-dimethylpiperazine

(R)-1-(4-chloro-pyrimidin-2-yl)-ethyl butyrate

(R)-1-(4-trifluoromethanesulfonyloxy-pyrimidin-2-yl)-ethyl butyrate

(R)-1-(4-hydroxypyrimidin-2-yl)ethyl butyrate

Downstream raw materials:

1R-[4-(4-benzyl-2R,6S-dimethyl-piperazin-1-yl)-pyrimidin-2-yl]-ethyl butyrate hydrochloride