(E)-3-<<<<6-<2-(methoxycarbonyl)ethenyl>-5-<<8-(4-methoxyphenyl)octyl>oxy>-2-pyridinyl>methyl>thio>methyl>benzoic acid methyl ester

Base Information

Chemical Name:(E)-3-<<<<6-<2-(methoxycarbonyl)ethenyl>-5-<<8-(4-methoxyphenyl)octyl>oxy>-2-pyridinyl>methyl>thio>methyl>benzoic acid methyl ester
CAS No.:149280-81-9
Molecular Formula:C₃₄H₄₁NO₆S
Molecular Weight:591.769
Hs Code.:

Synonyms:(E)-3-<<<<6-<2-(methoxycarbonyl)ethenyl>-5-<<8-(4-methoxyphenyl)octyl>oxy>-2-pyridinyl>methyl>thio>methyl>benzoic acid methyl ester

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Chemical Property of (E)-3-<<<<6-<2-(methoxycarbonyl)ethenyl>-5-<<8-(4-methoxyphenyl)octyl>oxy>-2-pyridinyl>methyl>thio>methyl>benzoic acid methyl ester

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Technology Process of (E)-3-<<<<6-<2-(methoxycarbonyl)ethenyl>-5-<<8-(4-methoxyphenyl)octyl>oxy>-2-pyridinyl>methyl>thio>methyl>benzoic acid methyl ester

There total 17 articles about (E)-3-<<<<6-<2-(methoxycarbonyl)ethenyl>-5-<<8-(4-methoxyphenyl)octyl>oxy>-2-pyridinyl>methyl>thio>methyl>benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 95902-29-7
methyl 3-(mercaptomethyl)benzoate

: (E)-3-{6-Chloromethyl-3-[8-(4-methoxy-phenyl)-octyloxy]-pyridin-2-yl}-acrylic acid methyl ester; hydrochloride

: 149280-81-9
(E)-3-<<<<6-<2-(methoxycarbonyl)ethenyl>-5-<<8-(4-methoxyphenyl)octyl>oxy>-2-pyridinyl>methyl>thio>methyl>benzoic acid methyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃;
DOI:10.1021/jm00070a015

Reference yield:

: 139140-55-9
7-octyn-1-yl tert-butyldiphenylsilyl ether

: 149280-81-9
(E)-3-<<<<6-<2-(methoxycarbonyl)ethenyl>-5-<<8-(4-methoxyphenyl)octyl>oxy>-2-pyridinyl>methyl>thio>methyl>benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 93 percent / Et₃N, CuI / (Ph₃P)2PdCl₂ / 4 h / 50 °C

2: 93 percent / H₂ / 5percent Pd-C / ethanol; ethyl acetate / 4 h

3: 1 M tetrabutylammonium fluoride / tetrahydrofuran / 4.5 h / Ambient temperature

4: 90 percent / triphenylphosphine, imidazole, I₂ / toluene / 0.5 h / 65 °C

5: K₂CO₃ / dimethylformamide / 1.5 h / 90 °C

6: toluene / 1 h / 50 °C

7: 50percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 15 h / Ambient temperature

8: trifluoroacetic anhydride / dimethylformamide / 18 h / Ambient temperature

9: SOCl₂ / toluene / 4 h / Ambient temperature

10: 79 percent / Cs₂CO₃ / dimethylformamide / 1.5 h / 60 °C

With 1H-imidazole; copper(l) iodide; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen; iodine; potassium carbonate; caesium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic anhydride; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00046a017

Reference yield:

: 139140-56-0
8-(4-methoxyphenyl)-7-octyn-1-yl tert-butyldiphenylsilyl ether

: 149280-81-9
(E)-3-<<<<6-<2-(methoxycarbonyl)ethenyl>-5-<<8-(4-methoxyphenyl)octyl>oxy>-2-pyridinyl>methyl>thio>methyl>benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 93 percent / H₂ / 5percent Pd-C / ethanol; ethyl acetate / 4 h

2: 1 M tetrabutylammonium fluoride / tetrahydrofuran / 4.5 h / Ambient temperature

3: 90 percent / triphenylphosphine, imidazole, I₂ / toluene / 0.5 h / 65 °C

4: K₂CO₃ / dimethylformamide / 1.5 h / 90 °C

5: toluene / 1 h / 50 °C

6: 50percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 15 h / Ambient temperature

7: trifluoroacetic anhydride / dimethylformamide / 18 h / Ambient temperature

8: SOCl₂ / toluene / 4 h / Ambient temperature

9: 79 percent / Cs₂CO₃ / dimethylformamide / 1.5 h / 60 °C

With 1H-imidazole; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen; iodine; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00046a017