4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER

Base Information

• Chemical Name: 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER
• CAS No.: 154548-45-5
• Molecular Formula: C16H19 N O5
• Molecular Weight: 305.331
• Hs Code.: 2933399090
• Mol file: 154548-45-5.mol

Synonyms:Ethyl1-benzyloxycarbonyl-4-oxo-3-piperidinecarboxylate

Chemical Property of 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER

Chemical Property:

• Boiling Point: 446.4±45.0 °C(Predicted)
• PKA: 11.06±0.20(Predicted)
• PSA: 72.91000
• Density: 1.238±0.06 g/cm3(Predicted)
• LogP: 1.71520
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-Benzyl3-ethyl4-oxopiperidine-1,3-dicarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER

There total 4 articles about 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.1%

ethyl 4-piperidone-3-carboxylate hydrochloride (4644-61-5) + benzyl chloroformate (501-53-1,94274-21-2) → 1-benzyloxycarbonyl-3-carboxylic acid ethyl ester-4-piperidone (154548-45-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1002/ardp.201800110

Reference yield: 89.8%

benzyl chloroformate (501-53-1,94274-21-2) + 1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate (98977-34-5) → 1-benzyloxycarbonyl-3-carboxylic acid ethyl ester-4-piperidone (154548-45-5)

Guidance literature:

1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate; With trifluoroacetic acid; In dichloromethane; at 5 - 10 ℃;

benzyl chloroformate; With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield: 78.0%

benzyl chloroformate (501-53-1,94274-21-2) → 1-benzyloxycarbonyl-3-carboxylic acid ethyl ester-4-piperidone (154548-45-5)

Guidance literature:

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride; With hydrogen; palladium dihydroxide; In methanol; under 2068.65 Torr;

benzyl chloroformate; With triethylamine; In dichloromethane; at 0 - 25 ℃; for 15h;

upstream raw materials:

ethyl 4-piperidone-3-carboxylate hydrochloride

benzyl chloroformate

1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate

C₉H₁₄O₃NC₆H₅

Downstream raw materials:

4-hydroxy-2-methylsulfanyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylic acid benzyl ester

8-benzyl 6-ethyl 1,4-dithia-8-azaspiro[4.5]decane-6,8-dicarboxylate

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