tert-butyl 2-amino-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate

Base Information

• Chemical Name: tert-butyl 2-amino-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate
• CAS No.: 1209487-56-8
• Molecular Formula: C₁₁H₁₈N₄O₂
• Molecular Weight: 238.29

Synonyms:tert-butyl 2-amino-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate

Chemical Property of tert-butyl 2-amino-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl2-Amino-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate ^*data from reagent suppliers

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Technology Process of tert-butyl 2-amino-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate

There total 11 articles about tert-butyl 2-amino-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C19H24N4O4 (1209488-61-8) → tert-butyl 2-amino-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate (1209487-56-8)

Guidance literature:

With hydrogen; 20% palladium(II) hydroxide on carbon; In tetrahydrofuran; methanol; water; at 20 ℃; for 4h;

Reference yield: 90.0%

tert-butyl 2-nitro-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate → tert-butyl 2-amino-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate (1209487-56-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 16h;

Reference yield:

Dimethyl-1-(2-((tert-butoxycarbonyl)amino)ethyl)-1H-pyrazole-3,5-dicarboxylate (1209492-68-1) → tert-butyl 2-amino-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate (1209487-56-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: potassium hydroxide; methanol / dichloromethane / 20 °C / Inert atmosphere

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 45 °C / Inert atmosphere

2.2: 0.5 h / 0 - 20 °C

3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.5 h / 0 - 20 °C / Inert atmosphere

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 20 °C

6.1: triethylamine; diphenyl phosphoryl azide / toluene / 4 h / 100 °C / Inert atmosphere

7.1: hydrogen / 20% palladium(II) hydroxide on carbon / water; tetrahydrofuran; methanol / 4 h / 20 °C

With methanol; diphenyl phosphoryl azide; water; hydrogen; sodium hydride; methanesulfonyl chloride; triethylamine; 1,1'-carbonyldiimidazole; potassium hydroxide; sodium hydroxide; 20% palladium(II) hydroxide on carbon; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;

upstream raw materials:

Dimethyl-1-(2-((tert-butoxycarbonyl)amino)ethyl)-1H-pyrazole-3,5-dicarboxylate

C₁₃H₁₉N₃O₆

C₁₃H₂₁N₃O₅

C₁₃H₂₀ClN₃O₄

Downstream raw materials:

C₁₄H₁₇N₅O

C₁₅H₁₈N₆O₂

tert-butyl 2-bromo-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxylate

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