N,N-dimethyl-5-(3-(1-methyl-2-oxopyrrolidin-3-yloxy)-5-(6-oxo-1,6-dihydropyrimidin-yl)phenoxy)pyrazine-2-carboxamide

Base Information

Chemical Name:N,N-dimethyl-5-(3-(1-methyl-2-oxopyrrolidin-3-yloxy)-5-(6-oxo-1,6-dihydropyrimidin-yl)phenoxy)pyrazine-2-carboxamide
CAS No.:1352570-06-9
Molecular Formula:C₂₂H₂₂N₆O₅
Molecular Weight:450.454
Hs Code.:

Synonyms:N,N-dimethyl-5-(3-(1-methyl-2-oxopyrrolidin-3-yloxy)-5-(6-oxo-1,6-dihydropyrimidin-yl)phenoxy)pyrazine-2-carboxamide

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Chemical Property of N,N-dimethyl-5-(3-(1-methyl-2-oxopyrrolidin-3-yloxy)-5-(6-oxo-1,6-dihydropyrimidin-yl)phenoxy)pyrazine-2-carboxamide

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Technology Process of N,N-dimethyl-5-(3-(1-methyl-2-oxopyrrolidin-3-yloxy)-5-(6-oxo-1,6-dihydropyrimidin-yl)phenoxy)pyrazine-2-carboxamide

There total 5 articles about N,N-dimethyl-5-(3-(1-methyl-2-oxopyrrolidin-3-yloxy)-5-(6-oxo-1,6-dihydropyrimidin-yl)phenoxy)pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₀N₆O₆

: 1352570-06-9
N,N-dimethyl-5-(3-(1-methyl-2-oxopyrrolidin-3-yloxy)-5-(6-oxo-1,6-dihydropyrimidin-yl)phenoxy)pyrazine-2-carboxamide

Guidance literature:: C₃₀H₃₀N₆O₆; With trifluoroacetic acid; In dichloromethane; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 88625-23-4
5-chloropyrazine-2-carbonyl chloride

: 1352570-06-9
N,N-dimethyl-5-(3-(1-methyl-2-oxopyrrolidin-3-yloxy)-5-(6-oxo-1,6-dihydropyrimidin-yl)phenoxy)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

2: N,N-dimethyl-formamide / 60 °C

3: trifluoroacetic acid / dichloromethane / 1 h

With triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1352571-59-5
C₃₀H₄₄N₂O₄Si₂

: 1352570-06-9
N,N-dimethyl-5-(3-(1-methyl-2-oxopyrrolidin-3-yloxy)-5-(6-oxo-1,6-dihydropyrimidin-yl)phenoxy)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 60 - 90 °C

3: N,N-dimethyl-formamide / 60 °C

4: trifluoroacetic acid / dichloromethane / 1 h

With tetrabutyl ammonium fluoride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;