[3-((R)-1-aminopropyl)-6-chloro-2-fluorophenyl](1H-pyrazol-4-yl)methanone

Base Information

Chemical Name:[3-((R)-1-aminopropyl)-6-chloro-2-fluorophenyl](1H-pyrazol-4-yl)methanone
CAS No.:1433947-23-9
Molecular Formula:C₁₃H₁₃ClFN₃O
Molecular Weight:281.717
Hs Code.:

Synonyms:[3-((R)-1-aminopropyl)-6-chloro-2-fluorophenyl](1H-pyrazol-4-yl)methanone

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Chemical Property of [3-((R)-1-aminopropyl)-6-chloro-2-fluorophenyl](1H-pyrazol-4-yl)methanone

Chemical Property:

Purity/Quality:

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Technology Process of [3-((R)-1-aminopropyl)-6-chloro-2-fluorophenyl](1H-pyrazol-4-yl)methanone

There total 7 articles about [3-((R)-1-aminopropyl)-6-chloro-2-fluorophenyl](1H-pyrazol-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433404-17-1
{(R)-1-[4-chloro-3-(1-dimethylsulfamoyl-1H-pyrazole-4-carbonyl)-2-fluorophenyl]propyl}carbamic acid tert-butyl ester

: 1433947-23-9
[3-((R)-1-aminopropyl)-6-chloro-2-fluorophenyl](1H-pyrazol-4-yl)methanone

Guidance literature:: With hydrogenchloride; In methanol; water; at 70 ℃; for 2h;

Reference yield:

: 1433401-71-8
[(R)-1-(4-chloro-2-fluoro-phenyl)-propyl]-carbamic acid tert-butyl ester

: 1433947-23-9
[3-((R)-1-aminopropyl)-6-chloro-2-fluorophenyl](1H-pyrazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 15 h / -70 - -65 °C

1.2: 1.08 h / -65 °C

1.3: 3 h / -65 °C

2.1: ammonium acetate; sodium periodate / water; acetone / 2 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; diethyl dicarbonate; potassium phosphate / 1,4-dioxane / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

4.1: hydrogenchloride / water; methanol / 2 h / 70 °C

With hydrogenchloride; potassium phosphate; sodium periodate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; ammonium acetate; diethyl dicarbonate; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; acetone;

Reference yield:

: 1433405-92-5
(R)-1-(4-chloro-2-fluorophenyl)propylamine L-aspartate

: 1433947-23-9
[3-((R)-1-aminopropyl)-6-chloro-2-fluorophenyl](1H-pyrazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C / Large scale

1.2: 20 °C / Large scale

2.1: n-butyllithium / tetrahydrofuran; hexane / 15 h / -70 - -65 °C

2.2: 1.08 h / -65 °C

2.3: 3 h / -65 °C

3.1: ammonium acetate; sodium periodate / water; acetone / 2 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; diethyl dicarbonate; potassium phosphate / 1,4-dioxane / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

5.1: hydrogenchloride / water; methanol / 2 h / 70 °C

With hydrogenchloride; potassium phosphate; sodium periodate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; ammonium acetate; diethyl dicarbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; acetone;