5(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>-3(E)-hexenoic acid

Base Information

Chemical Name:5(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>-3(E)-hexenoic acid
CAS No.:137650-26-1
Molecular Formula:C₂₃H₃₅NO₅
Molecular Weight:405.535
Hs Code.:

Synonyms:5(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>-3(E)-hexenoic acid

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Chemical Property of 5(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>-3(E)-hexenoic acid

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Technology Process of 5(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>-3(E)-hexenoic acid

There total 4 articles about 5(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>-3(E)-hexenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137650-15-8
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-2,6-dimethylphenyl)propanoate

: 137650-26-1
5(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>-3(E)-hexenoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / BF₃*Et₂O / CH₂Cl₂ / 16 h / 0 °C

2: Dibal-H / toluene / -78 °C

3: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 0.5 h, 2.) THF, hexane, from -78 deg C to 0 deg C, 1 h

4: 1.) dicyclohexylborane, 2.) H₂O₂ / 1.) THF, 0.5 h, 2.) THF, MeOH, 0.5 h

With n-butyllithium; boron trifluoride diethyl etherate; bis(cyclohexanyl)borane; dihydrogen peroxide; diisobutylaluminium hydride; In dichloromethane; toluene;
DOI:10.1021/jm00080a005

Reference yield:

: 137650-16-9
N-<(1,1-dimethylethoxy)carbonyl>-O-(1,1-dimethylethyl)-2,6-dimethyl-L-tyrosine methyl ester

: 137650-26-1
5(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>-3(E)-hexenoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Dibal-H / toluene / -78 °C

2: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 0.5 h, 2.) THF, hexane, from -78 deg C to 0 deg C, 1 h

3: 1.) dicyclohexylborane, 2.) H₂O₂ / 1.) THF, 0.5 h, 2.) THF, MeOH, 0.5 h

With n-butyllithium; bis(cyclohexanyl)borane; dihydrogen peroxide; diisobutylaluminium hydride; In toluene;
DOI:10.1021/jm00080a005

Reference yield:

: 137650-25-0
1,1-dimethylethyl <1(S)-<<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>methyl>-5-(trimethylsilyl)-2(E)-penten-4-ynyl>carbamate

: 137650-26-1
5(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>-3(E)-hexenoic acid

Guidance literature:: With bis(cyclohexanyl)borane; dihydrogen peroxide; Yield given. Multistep reaction; 1.) THF, 0.5 h, 2.) THF, MeOH, 0.5 h;
DOI:10.1021/jm00080a005