benzyl N-[(2S)-1-[4-(2-chlorophenyl)piperazin-1-yl]-1-oxo-6-(prop-2-enamido)hexan-2-yl]carbamate

Base Information

Chemical Name:benzyl N-[(2S)-1-[4-(2-chlorophenyl)piperazin-1-yl]-1-oxo-6-(prop-2-enamido)hexan-2-yl]carbamate
CAS No.:1400654-83-2
Molecular Formula:C₂₇H₃₃ClN₄O₄
Molecular Weight:513.036
Hs Code.:

Synonyms:benzyl N-[(2S)-1-[4-(2-chlorophenyl)piperazin-1-yl]-1-oxo-6-(prop-2-enamido)hexan-2-yl]carbamate

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Chemical Property of benzyl N-[(2S)-1-[4-(2-chlorophenyl)piperazin-1-yl]-1-oxo-6-(prop-2-enamido)hexan-2-yl]carbamate

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Technology Process of benzyl N-[(2S)-1-[4-(2-chlorophenyl)piperazin-1-yl]-1-oxo-6-(prop-2-enamido)hexan-2-yl]carbamate

There total 5 articles about benzyl N-[(2S)-1-[4-(2-chlorophenyl)piperazin-1-yl]-1-oxo-6-(prop-2-enamido)hexan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 39512-50-0
N-(o-Chlorophenyl)piperazine

: 366780-95-2
N_α-carbobenzyloxy-L-2-amino-6-acryloylaminohexanoic acid

: 1400654-83-2
benzyl N-[(2S)-1-[4-(2-chlorophenyl)piperazin-1-yl]-1-oxo-6-(prop-2-enamido)hexan-2-yl]carbamate

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/ml300241m

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 1400654-83-2
benzyl N-[(2S)-1-[4-(2-chlorophenyl)piperazin-1-yl]-1-oxo-6-(prop-2-enamido)hexan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3: sodium hydroxide / tetrahydrofuran; water / 18 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; HATU / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ml300241m

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1400654-83-2
benzyl N-[(2S)-1-[4-(2-chlorophenyl)piperazin-1-yl]-1-oxo-6-(prop-2-enamido)hexan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: sodium hydroxide / tetrahydrofuran; water / 18 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; HATU / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/ml300241m