1-tosyl-5-(3-(triisopropylsilyl)prop-2-ynyl)imidazolidin-2-one

Base Information

• Chemical Name: 1-tosyl-5-(3-(triisopropylsilyl)prop-2-ynyl)imidazolidin-2-one
• CAS No.: 1310539-00-4
• Molecular Formula: C₂₂H₃₄N₂O₃SSi
• Molecular Weight: 434.675
• Mol file: 1310539-00-4.mol

Synonyms:1-tosyl-5-(3-(triisopropylsilyl)prop-2-ynyl)imidazolidin-2-one

Chemical Property of 1-tosyl-5-(3-(triisopropylsilyl)prop-2-ynyl)imidazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-tosyl-5-(3-(triisopropylsilyl)prop-2-ynyl)imidazolidin-2-one

There total 4 articles about 1-tosyl-5-(3-(triisopropylsilyl)prop-2-ynyl)imidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N-(allylcarbamoyl)-4-methylbenzenesulfonamide (51506-31-1) + 1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one (181934-30-5) → 1-tosyl-5-(3-(triisopropylsilyl)prop-2-ynyl)imidazolidin-2-one (1310539-00-4)

Guidance literature:

With lithium chloride; palladium dichloride; In ethanol; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201100718

Reference yield:

triisopropylsilyl chloride (13154-24-0) → 1-tosyl-5-(3-(triisopropylsilyl)prop-2-ynyl)imidazolidin-2-one (1310539-00-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 - 0 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 0.75 h / 4 °C / Inert atmosphere

2.2: 0.92 h / 4 °C / Inert atmosphere

3.1: lithium chloride; palladium dichloride / ethanol / 20 °C / Inert atmosphere

With n-butyllithium; trimethylsilyl trifluoromethanesulfonate; lithium chloride; palladium dichloride; In tetrahydrofuran; ethanol; hexane; acetonitrile;

DOI:10.1002/anie.201100718

Reference yield:

Tosyl isocyanate (4083-64-1) → 1-tosyl-5-(3-(triisopropylsilyl)prop-2-ynyl)imidazolidin-2-one (1310539-00-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 1.67 h / 0 - 20 °C / Inert atmosphere

2: lithium chloride; palladium dichloride / ethanol / 20 °C / Inert atmosphere

With lithium chloride; palladium dichloride; In ethanol; dichloromethane;

DOI:10.1002/anie.201100718

upstream raw materials:

triisopropylsilyl chloride

N-(allylcarbamoyl)-4-methylbenzenesulfonamide

1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one

1-(triisopropylsilyl)-2-(trimethylsilyl)acetylene