9-benzhydryloxy-7-(4-fluoro-benzyl)-5-(2-trimethylsilanyl-ethoxy)-6,7-dihydro-pyrrolo[3,4-g]quinolin-8-one

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Chemical Name:9-benzhydryloxy-7-(4-fluoro-benzyl)-5-(2-trimethylsilanyl-ethoxy)-6,7-dihydro-pyrrolo[3,4-g]quinolin-8-one
CAS No.:684284-66-0
Molecular Formula:C₃₆H₃₅FN₂O₃Si
Molecular Weight:590.769
Hs Code.:

Synonyms:9-benzhydryloxy-7-(4-fluoro-benzyl)-5-(2-trimethylsilanyl-ethoxy)-6,7-dihydro-pyrrolo[3,4-g]quinolin-8-one

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Chemical Property of 9-benzhydryloxy-7-(4-fluoro-benzyl)-5-(2-trimethylsilanyl-ethoxy)-6,7-dihydro-pyrrolo[3,4-g]quinolin-8-one

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Technology Process of 9-benzhydryloxy-7-(4-fluoro-benzyl)-5-(2-trimethylsilanyl-ethoxy)-6,7-dihydro-pyrrolo[3,4-g]quinolin-8-one

There total 6 articles about 9-benzhydryloxy-7-(4-fluoro-benzyl)-5-(2-trimethylsilanyl-ethoxy)-6,7-dihydro-pyrrolo[3,4-g]quinolin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 684284-63-7
9-benzhydryloxy-7-(4-fluoro-benzyl)-5-(2-trimethylsilanyl-ethoxy)-pyrrolo[3,4-g]quinoline-6,8-dione

: 684284-66-0
9-benzhydryloxy-7-(4-fluoro-benzyl)-5-(2-trimethylsilanyl-ethoxy)-6,7-dihydro-pyrrolo[3,4-g]quinolin-8-one

Guidance literature:: 9-benzhydryloxy-7-(4-fluoro-benzyl)-5-(2-trimethylsilanyl-ethoxy)-pyrrolo[3,4-g]quinoline-6,8-dione; With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃;

With dmap; acetic anhydride; In dichloromethane; at 20 ℃; for 12h;

With 2,6-dimethylpyridine; triethylsilane; trimethylsilyl trifluoromethanesulfonate; at 20 ℃; for 12h;
DOI:10.1016/j.bmcl.2006.05.016

Reference yield:

: 684284-29-5
7-(4-fluoro-benzyl)-5,9-dihydroxy-pyrrolo[3,4-g]quinoline-6,8-dione

: 684284-66-0
9-benzhydryloxy-7-(4-fluoro-benzyl)-5-(2-trimethylsilanyl-ethoxy)-6,7-dihydro-pyrrolo[3,4-g]quinolin-8-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 63 percent / NaOH / dioxane; H₂O / 1 h / 20 °C

2.1: 80 percent / 1,2-dichloro-ethane / 3 h / 70 °C

3.1: 100 percent / K₂CO₃; 4-dimethylaminopyridine / tetrahydrofuran; H₂O / 12 h / 20 °C

4.1: 82 percent / DEAD; Ph₃P / CH₂Cl₂ / 3 h / 20 °C

5.1: aq. LiBH₄ / tetrahydrofuran / 0 - 20 °C

5.2: Ac₂O; DMAP / CH₂Cl₂ / 12 h / 20 °C

5.3: 47 percent / triethylsilane; TMSOTf; 2,6-lutidine / 12 h / 20 °C

With dmap; sodium hydroxide; lithium borohydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2006.05.016

Reference yield:

: 684284-30-8
carbonic acid ethyl ester 7-(4-fluoro-benzyl)-9-hydroxy-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester

: 684284-66-0
9-benzhydryloxy-7-(4-fluoro-benzyl)-5-(2-trimethylsilanyl-ethoxy)-6,7-dihydro-pyrrolo[3,4-g]quinolin-8-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 80 percent / 1,2-dichloro-ethane / 3 h / 70 °C

2.1: 100 percent / K₂CO₃; 4-dimethylaminopyridine / tetrahydrofuran; H₂O / 12 h / 20 °C

3.1: 82 percent / DEAD; Ph₃P / CH₂Cl₂ / 3 h / 20 °C

4.1: aq. LiBH₄ / tetrahydrofuran / 0 - 20 °C

4.2: Ac₂O; DMAP / CH₂Cl₂ / 12 h / 20 °C

4.3: 47 percent / triethylsilane; TMSOTf; 2,6-lutidine / 12 h / 20 °C

With dmap; lithium borohydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2006.05.016