(2S,3R)-4-((S)-1-Methoxycarbonyl-ethylamino)-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)-butyric acid methyl ester

Base Information

Chemical Name:(2S,3R)-4-((S)-1-Methoxycarbonyl-ethylamino)-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)-butyric acid methyl ester
CAS No.:120230-74-2
Molecular Formula:C₂₉H₃₂N₂O₄
Molecular Weight:472.584
Hs Code.:

Synonyms:(2S,3R)-4-((S)-1-Methoxycarbonyl-ethylamino)-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)-butyric acid methyl ester

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Chemical Property of (2S,3R)-4-((S)-1-Methoxycarbonyl-ethylamino)-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)-butyric acid methyl ester

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Technology Process of (2S,3R)-4-((S)-1-Methoxycarbonyl-ethylamino)-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)-butyric acid methyl ester

There total 4 articles about (2S,3R)-4-((S)-1-Methoxycarbonyl-ethylamino)-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 2491-20-5
L-alanine methyl ester hydrochloride

: 120230-71-9
methyl (2S,3S)-2-<(9-phenylfluorenyl)amino>-3-methyl-4-oxobutanoate

: 120230-74-2
(2S,3R)-4-((S)-1-Methoxycarbonyl-ethylamino)-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)-butyric acid methyl ester

Guidance literature:: With sodium cyanoborohydride; In methanol; for 1h; Ambient temperature;
DOI:10.1021/jo00274a037

Reference yield:

: 120230-62-8
dimethyl (S)-N-(9-phenyl-9H-fluoren-9-yl)aspartate

: 120230-74-2
(2S,3R)-4-((S)-1-Methoxycarbonyl-ethylamino)-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) potassium hexamethyldisilazide (KHMDS) / 1.) THF, toluene, -75 deg C, 1 h, 2.) -75 deg C, 2 h

2: 93 percent / diisobutylaluminiumhydride (DIBAL) / tetrahydrofuran; hexane / 1 h / -30 °C

3: N-chlorosuccinimide (NCS), (CH₃)2S / toluene / 4 h / -25 °C

4: 95 percent / NaCNBH₃ / methanol / 1 h / Ambient temperature

With N-chloro-succinimide; dimethylsulfide; potassium hexamethylsilazane; diisobutylaluminium hydride; sodium cyanoborohydride; In tetrahydrofuran; methanol; hexane; toluene;
DOI:10.1021/jo00274a037

Reference yield:

: 120230-68-4,120230-69-5
methyl (2S)-2-<(9-phenylfluorenyl)amino>-3-methyl-4-hydroxybutanoate

: 120230-74-2
(2S,3R)-4-((S)-1-Methoxycarbonyl-ethylamino)-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-chlorosuccinimide (NCS), (CH₃)2S / toluene / 4 h / -25 °C

2: 95 percent / NaCNBH₃ / methanol / 1 h / Ambient temperature

With N-chloro-succinimide; dimethylsulfide; sodium cyanoborohydride; In methanol; toluene;
DOI:10.1021/jo00274a037