1-fluoro-2,3,4-trimethylbenzene

Base Information

• Chemical Name: 1-fluoro-2,3,4-trimethylbenzene
• CAS No.: 52547-99-6
• Molecular Formula: C₉H₁₁F
• Molecular Weight: 138.185
• Mol file: 52547-99-6.mol

Synonyms:1-fluoro-2,3,4-trimethylbenzene

Chemical Property of 1-fluoro-2,3,4-trimethylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-fluoro-2,3,4-trimethylbenzene

There total 2 articles about 1-fluoro-2,3,4-trimethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,3-trimethylbenzene (526-73-8) → 2-(fluoromethyl)-1,3-dimethylbenzene (62037-90-5) + 1-fluoro-2,3,4-trimethylbenzene (52547-99-6) + 2,3-Dimethylbenzyl fluoride (117455-55-7)

Guidance literature:

With caesium fluoroxysulphate; In acetonitrile; at 35 - 40 ℃; for 1h; Yield given. Yields of byproduct given;

DOI:10.1021/jo00026a032

Reference yield:

1,2,3-trimethylbenzene (526-73-8) → 1-fluoro-3,4,5-trimethylbenzene (52547-91-8) + 1-fluoro-2,3,4-trimethylbenzene (52547-99-6)

Guidance literature:

With xenon difluoride; hydrogen fluoride; In dichloromethane; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00161a017

Reference yield:

1-fluoro-2,3,4-trimethylbenzene (52547-99-6) → 1,2-difluoro-3,4,5-trimethylbenzene (85649-61-2)

Guidance literature:

With xenon difluoride; hydrogen fluoride; In dichloromethane; at 25 ℃; Yield given;

DOI:10.1021/jo00161a017

upstream raw materials:

1,2,3-trimethylbenzene

Downstream raw materials:

1,2-difluoro-3,4,5-trimethylbenzene

Refernces

• 1、 Stavber, Stojan,Zupan, Marko. "Effect of Catalyst on the Fluorination of Methyl-Substituted Benzenes with Xenon Difluoride". . p. 2223 - 2226. Retrieved 2007/10/02.