norsampsone B

Base Information

Chemical Name:norsampsone B
CAS No.:1613505-86-4
Molecular Formula:C₃₂H₄₄O₃
Molecular Weight:476.7
Hs Code.:

Synonyms:norsampsone B

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of norsampsone B

Chemical Property:

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Technology Process of norsampsone B

There total 6 articles about norsampsone B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: C₃₅H₅₂O₅

: 1613505-85-3
norsampsone A

: 1613505-86-4
norsampsone B

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.0833333h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/acs.jnatprod.8b00763

Reference yield:

: 20633-28-7
3,3-dimethyl-5-oxo-5-phenylpentanoic acid

: 1613505-85-3
norsampsone A

: 1613505-86-4
norsampsone B

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; pivaloyl chloride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

1.2: 20 h / 0 - 20 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / benzene / 36 h / Reflux; Dean-Stark; Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.08 h / -78 °C / Inert atmosphere

3.2: 7 h / -78 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5.1: triphenylphosphine; 1H-imidazole; iodine / toluene / 0.08 h / 20 °C / Inert atmosphere

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

6.2: 48 h / 0 - 20 °C / Inert atmosphere

7.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

With 1H-imidazole; lithium aluminium tetrahydride; potassium tert-butylate; iodine; sodium hexamethyldisilazane; pivaloyl chloride; sodium hydride; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil; benzene; 7.1: |Dieckmann Condensation;
DOI:10.1021/acs.jnatprod.8b00763

Reference yield:

: C₂₅H₂₉NO₅

: 1613505-85-3
norsampsone A

: 1613505-86-4
norsampsone B

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.08 h / -78 °C / Inert atmosphere

1.2: 7 h / -78 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: triphenylphosphine; 1H-imidazole; iodine / toluene / 0.08 h / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

4.2: 48 h / 0 - 20 °C / Inert atmosphere

5.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

With 1H-imidazole; lithium aluminium tetrahydride; potassium tert-butylate; iodine; sodium hexamethyldisilazane; sodium hydride; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil; 5.1: |Dieckmann Condensation;
DOI:10.1021/acs.jnatprod.8b00763