7,7-dichloro-1,2,4,5,6,8-hexahydrocyclopenta[d]azepin-3-yl-p-tolylsulfone

Base Information

• Chemical Name: 7,7-dichloro-1,2,4,5,6,8-hexahydrocyclopenta[d]azepin-3-yl-p-tolylsulfone
• CAS No.: 185899-66-5
• Molecular Formula: C₁₆H₁₉Cl₂NO₂S
• Molecular Weight: 360.304
• Mol file: 185899-66-5.mol

Synonyms:7,7-dichloro-1,2,4,5,6,8-hexahydrocyclopenta[d]azepin-3-yl-p-tolylsulfone

Chemical Property of 7,7-dichloro-1,2,4,5,6,8-hexahydrocyclopenta[d]azepin-3-yl-p-tolylsulfone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7,7-dichloro-1,2,4,5,6,8-hexahydrocyclopenta[d]azepin-3-yl-p-tolylsulfone

There total 1 articles about 7,7-dichloro-1,2,4,5,6,8-hexahydrocyclopenta[d]azepin-3-yl-p-tolylsulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dichloro-9-methylene-6-azaspiro[2,6]non-6-yl-p-tolylsulfone (185899-65-4) → 7,7-dichloro-1,2,4,5,6,8-hexahydrocyclopenta[d]azepin-3-yl-p-tolylsulfone (185899-66-5)

Guidance literature:

at 480 ℃; under 2E-05 Torr;

DOI:10.1021/ja9634987

Reference yield: 34.2%

chloroform (67-66-3,8013-54-5) + 7,7-dichloro-1,2,4,5,6,8-hexahydrocyclopenta[d]azepin-3-yl-p-tolylsulfone (185899-66-5) → 9,9,11,11-tetrachloro-4-azatricyclo[5.3.1.0]undec-4-yl-p-tolylsulfone

Guidance literature:

With sodium hydroxide; cetyltrimethylammonim bromide; In dichloromethane; water; at 90 ℃; for 18h;

Reference yield:

chloroform (67-66-3,8013-54-5) + 7,7-dichloro-1,2,4,5,6,8-hexahydrocyclopenta[d]azepin-3-yl-p-tolylsulfone (185899-66-5) → 9,9,11,11-Tetrachloro-4-(toluene-4-sulfonyl)-4-aza-tricyclo[5.3.1.01,7]undecane (185899-67-6)

Guidance literature:

With sodium hydroxide; C₁₉H₃₃N(CH₃)3Br; In ethanol; dichloromethane; at 90 ℃; for 18h;

DOI:10.1021/ja9634987

upstream raw materials:

1,1-dichloro-9-methylene-6-azaspiro[2,6]non-6-yl-p-tolylsulfone

Downstream raw materials:

9,9,11,11-Tetrachloro-4-(toluene-4-sulfonyl)-4-aza-tricyclo[5.3.1.0^1,7]undecane

8,11-dichloro-N-tosyl-3-aza[5]metacyclophane

11-chloro-N-tosyl-3-aza[5]metacyclophane

7-chloro-1,2,4,5,6,8-hexahydrocyclopenta[d]azepin-3-yl-p-tolylsulfone