5t-hydroxymethyl-3-[(2-methyl-[1,3]dioxolan-2-yl)-acetyl]-oxazolidine-4r-carboxylic acid methyl ester

Base Information

• Chemical Name: 5t-hydroxymethyl-3-[(2-methyl-[1,3]dioxolan-2-yl)-acetyl]-oxazolidine-4r-carboxylic acid methyl ester
• CAS No.: 66646-75-1
• Molecular Formula: C₁₂H₁₉NO₇
• Molecular Weight: 289.285
• Mol file: 66646-75-1.mol

Synonyms:5t-hydroxymethyl-3-[(2-methyl-[1,3]dioxolan-2-yl)-acetyl]-oxazolidine-4r-carboxylic acid methyl ester

Chemical Property of 5t-hydroxymethyl-3-[(2-methyl-[1,3]dioxolan-2-yl)-acetyl]-oxazolidine-4r-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5t-hydroxymethyl-3-[(2-methyl-[1,3]dioxolan-2-yl)-acetyl]-oxazolidine-4r-carboxylic acid methyl ester

There total 1 articles about 5t-hydroxymethyl-3-[(2-methyl-[1,3]dioxolan-2-yl)-acetyl]-oxazolidine-4r-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-methyl-[1,3]dioxolan-2-yl)-acetic acid (5735-97-7) → 5t-hydroxymethyl-3-[(2-methyl-[1,3]dioxolan-2-yl)-acetyl]-oxazolidine-4r-carboxylic acid methyl ester (66646-75-1)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) benzene, (ii) /BRN= 118605/, CH₂Cl₂, (iii) DCC

2: NaOMe / methanol

3: H₂ / Pd-C / methanol / 70 °C / 22800 Torr

With hydrogen; sodium methylate; palladium on activated charcoal; In methanol;

DOI:10.1248/cpb.26.448

Reference yield:

5t-hydroxymethyl-3-[(2-methyl-[1,3]dioxolan-2-yl)-acetyl]-oxazolidine-4r-carboxylic acid methyl ester (66646-75-1) → 3-(3-oxo-butyryl)-5t-(phenylselanyl-methyl)-oxazolidine-4r-carboxylic acid methyl ester (66646-87-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂

2: NaBH₄ / methanol

3: aq. HCl / acetone / 0.75 h / 50 °C

With hydrogenchloride; sodium tetrahydroborate; triethylamine; In methanol; dichloromethane; acetone;

DOI:10.1248/cpb.26.448

Reference yield:

5t-hydroxymethyl-3-[(2-methyl-[1,3]dioxolan-2-yl)-acetyl]-oxazolidine-4r-carboxylic acid methyl ester (66646-75-1) → 3-(2-diazo-3-oxo-butyryl)-5t-(phenylselanyl-methyl)-oxazolidine-4r-carboxylic acid methyl ester

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂

2: NaBH₄ / methanol

3: aq. HCl / acetone / 0.75 h / 50 °C

4: TsN₃ / acetonitrile / 3.5 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; 4-toluenesulfonyl azide; triethylamine; In methanol; dichloromethane; acetone; acetonitrile;

DOI:10.1248/cpb.26.448

upstream raw materials:

(2-methyl-[1,3]dioxolan-2-yl)-acetic acid

Downstream raw materials:

7-oxo-3t-(phenylselanyl-methyl)-(5rH)-4-oxa-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid methyl ester

3-(3-oxo-butyryl)-5t-(phenylselanyl-methyl)-oxazolidine-4r-carboxylic acid methyl ester

3-[(2-methyl-[1,3]dioxolan-2-yl)-acetyl]-5t-(phenylselanyl-methyl)-oxazolidine-4r-carboxylic acid methyl ester