5-[3-(6-bromo-1-methyl-1H-indazol-3-ylamino)-phenyl]-5-methyl-morpholin-3-one

Base Information

Chemical Name:5-[3-(6-bromo-1-methyl-1H-indazol-3-ylamino)-phenyl]-5-methyl-morpholin-3-one
CAS No.:1429869-67-9
Molecular Formula:C₁₉H₁₉BrN₄O₂
Molecular Weight:415.289
Hs Code.:

Synonyms:5-[3-(6-bromo-1-methyl-1H-indazol-3-ylamino)-phenyl]-5-methyl-morpholin-3-one

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Chemical Property of 5-[3-(6-bromo-1-methyl-1H-indazol-3-ylamino)-phenyl]-5-methyl-morpholin-3-one

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Technology Process of 5-[3-(6-bromo-1-methyl-1H-indazol-3-ylamino)-phenyl]-5-methyl-morpholin-3-one

There total 6 articles about 5-[3-(6-bromo-1-methyl-1H-indazol-3-ylamino)-phenyl]-5-methyl-morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1214899-85-0
6-bromo-1-methyl-1H-indazol-3-ylamine

: 1262858-67-2
rac-5-(3-bromophenyl)-5-methylmorpholin-3-one

: 1429869-67-9
5-[3-(6-bromo-1-methyl-1H-indazol-3-ylamino)-phenyl]-5-methyl-morpholin-3-one

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In water; toluene; at 120 ℃; for 20h; Inert atmosphere;

Reference yield:

: 1262858-65-0
(RS)-2-amino-2-(3-bromo-phenyl)-propionic acid hydrochloride

: 1429869-67-9
5-[3-(6-bromo-1-methyl-1H-indazol-3-ylamino)-phenyl]-5-methyl-morpholin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 72 h / 0 - 20 °C

2: potassium carbonate / dichloromethane / 3 h / 0 - 20 °C

3: potassium tert-butylate; tert-butyl alcohol / 0.5 h / Reflux

4: XPhos; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / water; toluene / 20 h / 120 °C / Inert atmosphere

With sodium tetrahydroborate; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; boron trifluoride diethyl etherate; potassium tert-butylate; potassium carbonate; tert-butyl alcohol; XPhos; In tetrahydrofuran; dichloromethane; water; toluene;

Reference yield:

: 1262858-66-1
rac-N-[1-(3-bromophenyl)-2-hydroxy-1-methylethyl]-2-chloroacetamide

: 1429869-67-9
5-[3-(6-bromo-1-methyl-1H-indazol-3-ylamino)-phenyl]-5-methyl-morpholin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate; tert-butyl alcohol / 0.5 h / Reflux

2: XPhos; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / water; toluene / 20 h / 120 °C / Inert atmosphere

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; tert-butyl alcohol; XPhos; In water; toluene;