Technology Process of 3-(N,N-dibutylamino)-4-phenoxy-5-iso-butylsulfonylbenzoic acid
There total 9 articles about 3-(N,N-dibutylamino)-4-phenoxy-5-iso-butylsulfonylbenzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C21H27NO5S; butyraldehyde;
With
trifluoroacetic acid;
In
acetonitrile;
at 0 ℃;
for 0.5h;
With
triethylsilane;
In
acetonitrile;
at 0 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium sulfite / water / 3 h / 0 - 20 °C
2.1: sodium hydroxide / water; methanol / 72 h / 20 °C
3.1: sulfuric acid; nitric acid / 1 h / 0 - 110 °C
4.1: sodium hydrogencarbonate / water / 85 °C
5.1: thionyl chloride / 60 °C
6.1: ammonium chloride; iron / water; ethanol / 2.25 h / 85 °C
7.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C
8.1: lithium hydroxide / methanol; tetrahydrofuran / 2 h
9.1: trifluoroacetic acid / acetonitrile / 0.5 h / 0 °C
9.2: 0 - 20 °C
With
thionyl chloride; sulfuric acid; nitric acid; sodium tris(acetoxy)borohydride; iron; sodium hydrogencarbonate; ammonium chloride; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; sodium sulfite;
In
tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydrogencarbonate / water / 85 °C
2.1: thionyl chloride / 60 °C
3.1: ammonium chloride; iron / water; ethanol / 2.25 h / 85 °C
4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C
5.1: lithium hydroxide / methanol; tetrahydrofuran / 2 h
6.1: trifluoroacetic acid / acetonitrile / 0.5 h / 0 °C
6.2: 0 - 20 °C
With
thionyl chloride; sodium tris(acetoxy)borohydride; iron; sodium hydrogencarbonate; ammonium chloride; trifluoroacetic acid; lithium hydroxide;
In
tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; acetonitrile;
