(3S,4R)-3-ethoxycarbonyl-4-(4-fluorophenyl)-N-methylpiperidine-2,6-dione

Base Information

Chemical Name:(3S,4R)-3-ethoxycarbonyl-4-(4-fluorophenyl)-N-methylpiperidine-2,6-dione
CAS No.:188302-25-2
Molecular Formula:C₁₅H₁₆FNO₄
Molecular Weight:293.295
Hs Code.:

Synonyms:(3S,4R)-3-ethoxycarbonyl-4-(4-fluorophenyl)-N-methylpiperidine-2,6-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4R)-3-ethoxycarbonyl-4-(4-fluorophenyl)-N-methylpiperidine-2,6-dione

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Technology Process of (3S,4R)-3-ethoxycarbonyl-4-(4-fluorophenyl)-N-methylpiperidine-2,6-dione

There total 9 articles about (3S,4R)-3-ethoxycarbonyl-4-(4-fluorophenyl)-N-methylpiperidine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 71510-95-7
2-carboethoxy-N-methyl-acetamide

: C₁₄H₁₃FN₂O

: 188302-25-2,109887-52-7
(3S,4R)-3-ethoxycarbonyl-4-(4-fluorophenyl)-N-methylpiperidine-2,6-dione

Guidance literature:: C₁₄H₁₃FN₂O; With C₃₁H₄₄N₄O₄; ytterbium(III) triflate; In dichloromethane; at 35 ℃; for 0.5h; Molecular sieve; Inert atmosphere;

2-carboethoxy-N-methyl-acetamide; With triethylamine; In dichloromethane; at 40 ℃; for 72h; Reagent/catalyst; Solvent; Concentration; stereoselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1002/chem.201603056

Reference yield: 90.0%

: 76311-95-0
methyl 3-(methylamino)-3-oxopropanoate

: 459-32-5
(E)-4-fluorocinnamic acid

: 188302-25-2,109887-52-7
(3S,4R)-3-ethoxycarbonyl-4-(4-fluorophenyl)-N-methylpiperidine-2,6-dione

Guidance literature:: With cinchonidine; sodium hydride; In dimethyl sulfoxide; at -15 - 20 ℃; for 0.166667h; Reagent/catalyst;

Reference yield: 80.0%

: 71510-95-7
2-carboethoxy-N-methyl-acetamide

: 3-[3-(4-fluorophenyl)acryloyl]-(R)-4-phenyl-oxazolidin-2-one

: 188302-25-2,109887-52-7
(3S,4R)-3-ethoxycarbonyl-4-(4-fluorophenyl)-N-methylpiperidine-2,6-dione

Guidance literature:: 2-carboethoxy-N-methyl-acetamide; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; Inert atmosphere;

3-[3-(4-fluorophenyl)acryloyl]-(R)-4-phenyl-oxazolidin-2-one; In dimethyl sulfoxide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tetasy.2010.12.020