3-(3,4-dimethoxyphenyl)-7-(tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one

Base Information

Chemical Name:3-(3,4-dimethoxyphenyl)-7-(tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one
CAS No.:935659-66-8
Molecular Formula:C₂₂H₂₂O₆
Molecular Weight:382.413
Hs Code.:

Synonyms:3-(3,4-dimethoxyphenyl)-7-(tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one

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Chemical Property of 3-(3,4-dimethoxyphenyl)-7-(tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one

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Technology Process of 3-(3,4-dimethoxyphenyl)-7-(tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one

There total 9 articles about 3-(3,4-dimethoxyphenyl)-7-(tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 935659-63-5
3-iodo-7-((tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 935659-66-8
3-(3,4-dimethoxyphenyl)-7-(tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one

Guidance literature:: With 5% Pd(II)/C(eggshell); sodium carbonate; In 1,2-dimethoxyethane; water; at 45 ℃;
DOI:10.1021/jm900964r

Reference yield: 83.0%

: 3-iodo-6-((tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 935659-66-8
3-(3,4-dimethoxyphenyl)-7-(tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one

Guidance literature:: With palladium 10% on activated carbon; sodium carbonate; In 1,2-dimethoxyethane; water; at 45 ℃; for 4h;
DOI:10.1016/j.bmcl.2015.04.064

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 935659-66-8
3-(3,4-dimethoxyphenyl)-7-(tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: PPTS / CH₂Cl₂ / 4 h / 20 °C

2: 3 h / 95 °C

3: 11 g / pyridine; I₂ / CHCl₃ / 12 h / 20 °C

4: 89 percent / Na₂CO₃ / Pd⁽⁰⁾/C / 1,2-dimethoxy-ethane; H₂O / 1 h / 45 °C

With pyridine; iodine; pyridinium p-toluenesulfonate; sodium carbonate; palladium on activated charcoal; In 1,2-dimethoxyethane; dichloromethane; chloroform; water; 4: Suzuki-Miyaura cross-coupling reaction;
DOI:10.1016/j.tet.2007.01.062