2-(hex-5-en-yloxy)-5-[2-(hex-5-en-1-yloxy)phenyl]-1-methyl-1H-imidazole

Base Information

Chemical Name:2-(hex-5-en-yloxy)-5-[2-(hex-5-en-1-yloxy)phenyl]-1-methyl-1H-imidazole
CAS No.:1236074-00-2
Molecular Formula:C₂₂H₃₀N₂O₂
Molecular Weight:354.492
Hs Code.:

Synonyms:2-(hex-5-en-yloxy)-5-[2-(hex-5-en-1-yloxy)phenyl]-1-methyl-1H-imidazole

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Chemical Property of 2-(hex-5-en-yloxy)-5-[2-(hex-5-en-1-yloxy)phenyl]-1-methyl-1H-imidazole

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Technology Process of 2-(hex-5-en-yloxy)-5-[2-(hex-5-en-1-yloxy)phenyl]-1-methyl-1H-imidazole

There total 4 articles about 2-(hex-5-en-yloxy)-5-[2-(hex-5-en-1-yloxy)phenyl]-1-methyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1236073-91-8
5-iodo-1-methyl-2-(hex-5-en-1-yloxy)-1H-imidazole

: 1236073-85-0
2-(hex-5-en-1-yloxy)phenylboronic acid

: 1236074-00-2
2-(hex-5-en-yloxy)-5-[2-(hex-5-en-1-yloxy)phenyl]-1-methyl-1H-imidazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 105 ℃; for 1h; Inert atmosphere; Microwave irradiation;
DOI:10.1016/j.tet.2010.04.070 DOI:10.1002/ejoc.201100805

Reference yield:

: 821-41-0
5-Hexen-1-ol

: 1236074-00-2
2-(hex-5-en-yloxy)-5-[2-(hex-5-en-1-yloxy)phenyl]-1-methyl-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / Inert atmosphere

1.2: 6.5 h / 80 °C / Microwave irradiation

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 1 h / 105 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; mineral oil; 2.1: Suzuki coupling;
DOI:10.1002/ejoc.201100805

Reference yield:

: 64818-36-6
5-hexenyl methanesulfonate

: 1236074-00-2
2-(hex-5-en-yloxy)-5-[2-(hex-5-en-1-yloxy)phenyl]-1-methyl-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 20 - 70 °C

2: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 1 h / 105 °C / Microwave irradiation; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tetra-(n-butyl)ammonium iodide; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; water; N,N-dimethyl-formamide; 3: |Suzuki Coupling;
DOI:10.1021/jm400287v