4-Bromo-benzenesulfonic acid (2R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-2-ylmethyl ester

Base Information

Chemical Name:4-Bromo-benzenesulfonic acid (2R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-2-ylmethyl ester
CAS No.:475652-55-2
Molecular Formula:C₂₀H₁₈BrF₂N₃O₄S
Molecular Weight:514.347
Hs Code.:

Synonyms:4-Bromo-benzenesulfonic acid (2R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-2-ylmethyl ester

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Chemical Property of 4-Bromo-benzenesulfonic acid (2R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-2-ylmethyl ester

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Technology Process of 4-Bromo-benzenesulfonic acid (2R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-2-ylmethyl ester

There total 3 articles about 4-Bromo-benzenesulfonic acid (2R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R)-2-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)methyloxirane

: 475652-55-2
4-Bromo-benzenesulfonic acid (2R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: CuCn / tetrahydrofuran

2: 95 percent / m-CPBA / CH₂Cl₂

3: 96 percent / p-TSA / CH₂Cl₂

4: Et₃N / CH₂Cl₂

With toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; 1: Grignard alkylation;
DOI:10.1016/S0960-894X(02)00282-2

Reference yield:

: 186806-56-4
(R)-2-(2,4-Difluoro-phenyl)-1-[1,2,4]triazol-1-yl-hex-5-en-2-ol

: 475652-55-2
4-Bromo-benzenesulfonic acid (2R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / m-CPBA / CH₂Cl₂

2: 96 percent / p-TSA / CH₂Cl₂

3: Et₃N / CH₂Cl₂

With toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1016/S0960-894X(02)00282-2

Reference yield:

: 186806-59-7
(R)-2-(2,4-Difluoro-phenyl)-4-oxiranyl-1-[1,2,4]triazol-1-yl-butan-2-ol

: 475652-55-2
4-Bromo-benzenesulfonic acid (2R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / p-TSA / CH₂Cl₂

2: Et₃N / CH₂Cl₂

With toluene-4-sulfonic acid; triethylamine; In dichloromethane;
DOI:10.1016/S0960-894X(02)00282-2