(+)-1-{(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(trideuteromethoxy)methyl}cyclopropanecarboxylic acid

Base Information

Chemical Name:(+)-1-{(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(trideuteromethoxy)methyl}cyclopropanecarboxylic acid
CAS No.:1380604-61-4
Molecular Formula:C₂₃H₂₂Cl₂F₃NO₄
Molecular Weight:507.309
Hs Code.:

(+)-1-{(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(trideuteromethoxy)methyl}cyclopropanecarboxylic acid

Synonyms:(+)-1-{(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(trideuteromethoxy)methyl}cyclopropanecarboxylic acid

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Chemical Property of (+)-1-{(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(trideuteromethoxy)methyl}cyclopropanecarboxylic acid

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Technology Process of (+)-1-{(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(trideuteromethoxy)methyl}cyclopropanecarboxylic acid

There total 3 articles about (+)-1-{(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(trideuteromethoxy)methyl}cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380606-42-7
tert-Butyl 1-{(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(trideuteromethoxy)methyl}cyclopropanecarboxylate

: 1380604-60-3
(+)-1-{(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(trideuteromethoxy)methyl}cyclopropanecarboxylic acid

: 1380604-61-4
(+)-1-{(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(trideuteromethoxy)methyl}cyclopropanecarboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: ethyl (3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoate

: 1380604-60-3
(+)-1-{(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(trideuteromethoxy)methyl}cyclopropanecarboxylic acid

: 1380604-61-4
(+)-1-{(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(trideuteromethoxy)methyl}cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 50 °C

1.2: pH 1

2.1: pyridine; HATU / N,N-dimethyl-formamide / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With pyridine; water; HATU; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1297550-14-1
(+)-(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid

: 1380604-60-3
(+)-1-{(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(trideuteromethoxy)methyl}cyclopropanecarboxylic acid

: 1380604-61-4
(+)-1-{(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(trideuteromethoxy)methyl}cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; HATU / N,N-dimethyl-formamide / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With pyridine; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;