N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)benzamide

Base Information

Chemical Name:N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)benzamide
CAS No.:1292281-97-0
Molecular Formula:C₂₇H₂₅F₃N₆O₃
Molecular Weight:538.529
Hs Code.:

Synonyms:N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)benzamide

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Chemical Property of N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)benzamide

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Technology Process of N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)benzamide

There total 5 articles about N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1292281-67-4
N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-4-aminobenzamide

: 329-01-1
1-isocyanato-3-trifluoromethyl-benzene

: 1292281-97-0
N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)benzamide

Guidance literature:: In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmc.2011.01.067

Reference yield:

: 4,5-diamino-1-(4'-methoxybenzyl)-1H-pyrazole

: 1292281-97-0
N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 4 h / 80 °C

2: hydrogenchloride; tin(II) chloride dihdyrate / ethanol / 1.5 h / 80 °C

3: tetrahydrofuran / 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.067

Reference yield:

: 1292281-65-2
N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-4-nitrobenzamide

: 1292281-97-0
N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; tin(II) chloride dihdyrate / ethanol / 1.5 h / 80 °C

2: tetrahydrofuran / 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmc.2011.01.067