tert-Butyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-[(4-methylphenyl)-sulfonyl]oxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenate

Base Information

• Chemical Name: tert-Butyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-[(4-methylphenyl)-sulfonyl]oxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenate
• CAS No.: 475058-42-5
• Molecular Formula: C₃₀H₃₃N₃O₆S₂
• Molecular Weight: 595.741

Synonyms:tert-Butyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-[(4-methylphenyl)-sulfonyl]oxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenate

Chemical Property of tert-Butyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-[(4-methylphenyl)-sulfonyl]oxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenate

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Technology Process of tert-Butyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-[(4-methylphenyl)-sulfonyl]oxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenate

There total 1 articles about tert-Butyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-[(4-methylphenyl)-sulfonyl]oxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(tert-Butoxycarbonylmethylene)triphenylphosphorane (86302-43-4,35000-38-5) + p-toluenesulfonyl chloride (98-59-9) → tert-Butyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-[(4-methylphenyl)-sulfonyl]oxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenate (475058-42-5)

Guidance literature:

With dmap; In tetrahydrofuran; chloroform;

DOI:10.1016/j.bmcl.2003.10.060

Reference yield:

3-(dimethylamino)piperidine (50534-49-1) + tert-Butyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-[(4-methylphenyl)-sulfonyl]oxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenate (475058-42-5) → 3-{2-(3-dimethylamino-piperidin-1-yl)-8-[2-(4-isopropyl-thiazol-2-yl)-ethyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-acrylic acid tert-butyl ester

Guidance literature:

With TEA; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2003.10.060

Reference yield:

1-Methylhomopiperazine (4318-37-0) + tert-Butyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-[(4-methylphenyl)-sulfonyl]oxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenate (475058-42-5) → 3-[8-[2-(4-isopropyl-thiazol-2-yl)-ethyl]-2-(4-methyl-[1,4]diazepan-1-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-acrylic acid tert-butyl ester

Guidance literature:

With TEA; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2003.10.060

upstream raw materials:

(tert-Butoxycarbonylmethylene)triphenylphosphorane

p-toluenesulfonyl chloride

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