C₁₀H₁₂N₂O₃

Base Information

• Chemical Name: C₁₀H₁₂N₂O₃
• CAS No.: 125023-39-4
• Molecular Formula: C₁₀H₁₂N₂O₃
• Molecular Weight: 208.217
• Mol file: 125023-39-4.mol

Synonyms:C₁₀H₁₂N₂O₃

Chemical Property of C₁₀H₁₂N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₀H₁₂N₂O₃

There total 4 articles about C₁₀H₁₂N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-6,N-dimethylbenzamide (95330-31-7) → C10H12N2O3 (125023-39-4)

Guidance literature:

With acetic acid; sodium nitrite; In acetic anhydride; at 0 ℃;

DOI:10.1021/jo00291a058

Reference yield:

N-tert-Butyl-N-methyl-2-methoxybenzamide (95330-46-4) → C10H12N2O3 (125023-39-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) TMEDA, sec-Butyllithium (1.35 M in Cyclohexane) / 1) THf, -78 deg C, 1 h, 2) -78 deg C, 1 h; room temperature

2: trifluoroacetic acid / 1) room temperature, 15 min, 2) reflux, 2 h

3: NaNO₂/acetic acid / acetic anhydride / 0 °C

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; acetic acid; trifluoroacetic acid; sodium nitrite; In acetic anhydride;

DOI:10.1021/jo00291a058

Reference yield:

N-tert-Butyl-N-methyl-2-methoxy-6-methylbenzamide (95330-45-3) → C10H12N2O3 (125023-39-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / 1) room temperature, 15 min, 2) reflux, 2 h

2: NaNO₂/acetic acid / acetic anhydride / 0 °C

With acetic acid; trifluoroacetic acid; sodium nitrite; In acetic anhydride;

DOI:10.1021/jo00291a058

upstream raw materials:

2-methoxy-6,N-dimethylbenzamide

N-tert-Butyl-N-methyl-2-methoxybenzamide

N-tert-Butyl-N-methyl-2-methoxy-6-methylbenzamide

2-Methoxybenzoyl chloride

Downstream raw materials:

2-methoxy-6-methyl-benzoic acid

Refernces