(E)-N'-(3-nitrobenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide

Base Information

Chemical Name:(E)-N'-(3-nitrobenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide
CAS No.:1285537-05-4
Molecular Formula:C₁₇H₁₂ClN₅O₃
Molecular Weight:369.767
Hs Code.:

Synonyms:(E)-N'-(3-nitrobenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide

Suppliers and Price of (E)-N'-(3-nitrobenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-N'-(3-nitrobenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide

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Technology Process of (E)-N'-(3-nitrobenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide

There total 3 articles about (E)-N'-(3-nitrobenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 370096-67-6,890012-50-7
3-(4-cholorophenyl)-1H-pyrazole-5-carbohydrazide

: 99-61-6
3-nitro-benzaldehyde

: 1285537-05-4
(E)-N'-(3-nitrobenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide

Guidance literature:: With acetic acid; In methanol; for 6h; Reflux;
DOI:10.1016/j.bmcl.2012.05.063

Reference yield:

: 99-91-2
para-chloroacetophenone

: 1285537-05-4
(E)-N'-(3-nitrobenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: hydrazine hydrate / ethanol / 6 h / Reflux

3.1: acetic acid / methanol / 6 h / Reflux

With sodium methylate; hydrazine hydrate; acetic acid; In tetrahydrofuran; methanol; ethanol;
DOI:10.1016/j.bmcl.2012.05.063

Reference yield:

: 5814-38-0
ethyl 4-chlorobenzoylpyruvate

: 1285537-05-4
(E)-N'-(3-nitrobenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 6 h / Reflux

2: acetic acid / methanol / 6 h / Reflux

With hydrazine hydrate; acetic acid; In methanol; ethanol;
DOI:10.1016/j.bmcl.2012.05.063