Technology Process of Z-Trp-Nle-gAsp(OBzl)-COCH2CH2C6H5
There total 3 articles about Z-Trp-Nle-gAsp(OBzl)-COCH2CH2C6H5 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1) N-methylmorpholine, isobutyl chloroformate, 2) N,N-diisopropylethylamine / 1) DMF, 0 deg C, 5 min, 2) a) 0 deg C, 30 min, b) r.t., 30 min
2: benzene / acetonitrile / 3 h / Ambient temperature
3: (benzotriazolyloxy)tris(dimethylamino)phosphonium hexafluorophosphate, N,N-diisopropylethylamine / dimethylformamide / 1 h / Ambient temperature
4: 1) F3COOH, 2) N,N-diisopropylethylamine / 1) r.t., 30 min, 2) DMF, r.t., 3 h
With
4-methyl-morpholine; bis-(trifluoroacetoxy)-iodo-benzene; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; isobutyl chloroformate;
In
N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00130a018
- Guidance literature:
-
Multi-step reaction with 3 steps
1: benzene / acetonitrile / 3 h / Ambient temperature
2: (benzotriazolyloxy)tris(dimethylamino)phosphonium hexafluorophosphate, N,N-diisopropylethylamine / dimethylformamide / 1 h / Ambient temperature
3: 1) F3COOH, 2) N,N-diisopropylethylamine / 1) r.t., 30 min, 2) DMF, r.t., 3 h
With
bis-(trifluoroacetoxy)-iodo-benzene; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00130a018
- Guidance literature:
-
Multi-step reaction with 2 steps
1: (benzotriazolyloxy)tris(dimethylamino)phosphonium hexafluorophosphate, N,N-diisopropylethylamine / dimethylformamide / 1 h / Ambient temperature
2: 1) F3COOH, 2) N,N-diisopropylethylamine / 1) r.t., 30 min, 2) DMF, r.t., 3 h
With
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
N,N-dimethyl-formamide;
DOI:10.1021/jm00130a018