25-<(methoxymethyl)oxy>vitamin D2 tert-butyldimethylsilyl ether

Base Information

Chemical Name:25-<(methoxymethyl)oxy>vitamin D2 tert-butyldimethylsilyl ether
CAS No.:100858-28-4
Molecular Formula:C₃₆H₆₂O₃Si
Molecular Weight:570.972
Hs Code.:

Synonyms:25-<(methoxymethyl)oxy>vitamin D2 tert-butyldimethylsilyl ether

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Chemical Property of 25-<(methoxymethyl)oxy>vitamin D2 tert-butyldimethylsilyl ether

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of 25-<(methoxymethyl)oxy>vitamin D2 tert-butyldimethylsilyl ether

There total 6 articles about 25-<(methoxymethyl)oxy>vitamin D2 tert-butyldimethylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100858-20-6,100937-69-7
de-A,B-8β-(benzoyloxy)-25-<(methoxymethyl)oxy>cholest-23-yn-22-ol

: 100858-28-4
25-<(methoxymethyl)oxy>vitamin D2 tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 6 steps

1: quinoline, H₂ / 10percent Pd/BaSO₄ / methanol / 0.13 h / 93.09 Torr

2: 95 percent / (4-dimethylamino)pyridine (DMAP), pyridine / 0 °C

3: 1.) Cu₂I₂ / 1.) Et₂O, 0 deg C, 30 min, 2.) Et₂O, RT, 48 h

4: 100 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

5: 100 percent / pyridinium dichromate, pyridinium p-toluenesulfonate / CH₂Cl₂ / 24 h / Ambient temperature

6: 1.) n-BuLi / 1.) hexane, THF, -70 deg C, 30 min, 2.) THF, -70 deg C, 90 min

With pyridine; quinoline; dmap; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; copper (I) iodide; hydrogen; pyridinium p-toluenesulfonate; Pd-BaSO₄; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jo00358a018

Reference yield:

: 100858-25-1
(22E,24S)-de-A,B-25-[(methoxymethyl)oxy]ergost-22-en-8β-ol

: 100858-28-4
25-<(methoxymethyl)oxy>vitamin D2 tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / pyridinium dichromate, pyridinium p-toluenesulfonate / CH₂Cl₂ / 24 h / Ambient temperature

2: 1.) n-BuLi / 1.) hexane, THF, -70 deg C, 30 min, 2.) THF, -70 deg C, 90 min

With dipyridinium dichromate; n-butyllithium; pyridinium p-toluenesulfonate; In dichloromethane;
DOI:10.1021/jo00358a018

Reference yield:

: 100858-22-8
(22R,23Z)-de-A,B-8β-(benzoyloxy)-25-<(methoxymethyl)oxy>cholest-23-en-ol

: 100858-28-4
25-<(methoxymethyl)oxy>vitamin D2 tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / (4-dimethylamino)pyridine (DMAP), pyridine / 0 °C

2: 1.) Cu₂I₂ / 1.) Et₂O, 0 deg C, 30 min, 2.) Et₂O, RT, 48 h

3: 100 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

4: 100 percent / pyridinium dichromate, pyridinium p-toluenesulfonate / CH₂Cl₂ / 24 h / Ambient temperature

5: 1.) n-BuLi / 1.) hexane, THF, -70 deg C, 30 min, 2.) THF, -70 deg C, 90 min

With pyridine; dmap; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; copper (I) iodide; pyridinium p-toluenesulfonate; In diethyl ether; dichloromethane;
DOI:10.1021/jo00358a018