(+/-)-α-(R^*)-<2-ethyl>-α-(2-chlorophenyl)-2(R^*)-piperidineacetamide

Base Information

• Chemical Name: (+/-)-α-(R^*)-<2-ethyl>-α-(2-chlorophenyl)-2(R^*)-piperidineacetamide
• CAS No.: 96914-33-9
• Molecular Formula: C₂₁H₃₄ClN₃O
• Molecular Weight: 379.973
• Mol file: 96914-33-9.mol

Synonyms:(+/-)-α-(R^*)-<2-ethyl>-α-(2-chlorophenyl)-2(R^*)-piperidineacetamide

Chemical Property of (+/-)-α-(R^*)-<2-ethyl>-α-(2-chlorophenyl)-2(R^*)-piperidineacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-α-(R^*)-<2-ethyl>-α-(2-chlorophenyl)-2(R^*)-piperidineacetamide

There total 1 articles about (+/-)-α-(R^*)-<2-ethyl>-α-(2-chlorophenyl)-2(R^*)-piperidineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

(+/-)-α-<2-ethyl>-α-(2-chlorophenyl)-2-pyridineacetamide (91257-11-3) → (+/-)-α-(R*)-<2-ethyl>-α-(2-chlorophenyl)-2(R*)-piperidineacetamide (96914-33-9)

Guidance literature:

With sulfuric acid; hydrogen; platinum(IV) oxide; In acetic acid; at 75 ℃; for 4h; under 60 Torr;

DOI:10.1021/jm00147a029

Reference yield: 79.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + (+/-)-α-(R*)-<2-ethyl>-α-(2-chlorophenyl)-2(R*)-piperidineacetamide (96914-33-9) → (4R,4aR)-4-(2-Chloro-phenyl)-4-(2-diisopropylamino-ethyl)-4,4a,5,6,7,8-hexahydro-pyrido[1,2-c]pyrimidin-3-one (91257-09-9)

Guidance literature:

at 80 ℃; for 12.5h;

DOI:10.1021/jm00147a029

Reference yield:

(+/-)-α-(R*)-<2-ethyl>-α-(2-chlorophenyl)-2(R*)-piperidineacetamide (96914-33-9) → (4R,4aR)-4-(2-Chloro-phenyl)-4-(2-diisopropylamino-ethyl)-octahydro-pyrido[1,2-c]pyrimidin-3-one (96914-46-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / 12.5 h / 80 °C

2: 65 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jm00147a029

upstream raw materials:

(+/-)-α-<2-ethyl>-α-(2-chlorophenyl)-2-pyridineacetamide

Downstream raw materials:

(4R,4aR)-4-(2-Chloro-phenyl)-4-(2-diisopropylamino-ethyl)-4,4a,5,6,7,8-hexahydro-pyrido[1,2-c]pyrimidin-3-one

(4R,4aR)-4-(2-Chloro-phenyl)-4-(2-diisopropylamino-ethyl)-octahydro-pyrido[1,2-c]pyrimidin-3-one