8-benzyloxy-1-benzyloxymethyl-5,7-dimethoxy-6-methyl-3-triisopropylsilanyloxymethyl-1H-isoquinoline-2-carboxylic acid methyl ester

Base Information

Chemical Name:8-benzyloxy-1-benzyloxymethyl-5,7-dimethoxy-6-methyl-3-triisopropylsilanyloxymethyl-1H-isoquinoline-2-carboxylic acid methyl ester
CAS No.:864933-22-2
Molecular Formula:C₃₉H₅₃NO₇Si
Molecular Weight:675.938
Hs Code.:

8-benzyloxy-1-benzyloxymethyl-5,7-dimethoxy-6-methyl-3-triisopropylsilanyloxymethyl-1<i>H</i>-isoquinoline-2-carboxylic acid methyl ester

Synonyms:8-benzyloxy-1-benzyloxymethyl-5,7-dimethoxy-6-methyl-3-triisopropylsilanyloxymethyl-1H-isoquinoline-2-carboxylic acid methyl ester

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Chemical Property of 8-benzyloxy-1-benzyloxymethyl-5,7-dimethoxy-6-methyl-3-triisopropylsilanyloxymethyl-1H-isoquinoline-2-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 8-benzyloxy-1-benzyloxymethyl-5,7-dimethoxy-6-methyl-3-triisopropylsilanyloxymethyl-1H-isoquinoline-2-carboxylic acid methyl ester

There total 5 articles about 8-benzyloxy-1-benzyloxymethyl-5,7-dimethoxy-6-methyl-3-triisopropylsilanyloxymethyl-1H-isoquinoline-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 864933-21-1
8-benzyloxy-5,7-dimethoxy-6-methyl-3-triisopropylsilanyloxymethyl-isoquinoline

: 66222-28-4
(benzyloxymethyl)tributylstannane

: 79-22-1
methyl chloroformate

: 864933-22-2
8-benzyloxy-1-benzyloxymethyl-5,7-dimethoxy-6-methyl-3-triisopropylsilanyloxymethyl-1H-isoquinoline-2-carboxylic acid methyl ester

: 1384282-92-1
C₃₅H₅₃NO₆Si

Guidance literature:: (benzyloxymethyl)tributylstannane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h; Inert atmosphere;

8-benzyloxy-5,7-dimethoxy-6-methyl-3-triisopropylsilanyloxymethyl-isoquinoline; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

methyl chloroformate; In tetrahydrofuran; hexane; Inert atmosphere;
DOI:10.1016/j.tet.2012.02.043

Reference yield: 79.0%

: 864933-21-1
8-benzyloxy-5,7-dimethoxy-6-methyl-3-triisopropylsilanyloxymethyl-isoquinoline

: 66222-28-4
(benzyloxymethyl)tributylstannane

: 79-22-1
methyl chloroformate

: 864933-22-2
8-benzyloxy-1-benzyloxymethyl-5,7-dimethoxy-6-methyl-3-triisopropylsilanyloxymethyl-1H-isoquinoline-2-carboxylic acid methyl ester

Guidance literature:: (benzyloxymethyl)tributylstannane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h;

8-benzyloxy-5,7-dimethoxy-6-methyl-3-triisopropylsilanyloxymethyl-isoquinoline; In tetrahydrofuran; hexane; at 78 ℃; for 2h;

methyl chloroformate; In tetrahydrofuran; hexane; at -78 ℃;
DOI:10.1021/ja0535817

Reference yield:

: C₃₃H₄₉NO₄Si

: 864933-22-2
8-benzyloxy-1-benzyloxymethyl-5,7-dimethoxy-6-methyl-3-triisopropylsilanyloxymethyl-1H-isoquinoline-2-carboxylic acid methyl ester

: 1384282-92-1
C₃₅H₅₃NO₆Si

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere; sealed flask

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

2.3: Inert atmosphere

With copper(l) iodide; n-butyllithium; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.02.043