Carbamic acid, [[2-(hydroxymethyl)cyclopropyl]methyl]-, 1,1-dimethylethyl

Base Information

• Chemical Name: Carbamic acid, [[2-(hydroxymethyl)cyclopropyl]methyl]-, 1,1-dimethylethyl
• CAS No.: 153861-59-7
• Molecular Formula: C₁₀H₁₉NO₃
• Molecular Weight: 201.266
• Mol file: 153861-59-7.mol

Synonyms:N-Boc((1R,2S)-2-(aminomethyl)cyclopropyl)methanol;tert-butyl N-{[(1R,2S)-2-(hydroxymethyl)cyclopropyl]methyl}carbamate;Carbamic acid, [[2-(hydroxymethyl)cyclopropyl]methyl]-, 1,1-dimethylethyl ester, (1R-cis)- (9CI)

Chemical Property of Carbamic acid, [[2-(hydroxymethyl)cyclopropyl]methyl]-, 1,1-dimethylethyl

Chemical Property:

• PSA: 58.56000
• LogP: 1.53040

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [[2-(hydroxymethyl)cyclopropyl]methyl]-, 1,1-dimethylethyl

There total 15 articles about Carbamic acid, [[2-(hydroxymethyl)cyclopropyl]methyl]-, 1,1-dimethylethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1R,2S)-2-<(Benzyloxy)methyl>-1-<methyl>cyclopropane (153861-55-3) → ((1R,2S)-2-Hydroxymethyl-cyclopropylmethyl)-carbamic acid tert-butyl ester (153861-59-7,167255-48-3,167255-49-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 3h; Ambient temperature;

DOI:10.1021/jo00080a017

Reference yield:

(1R,2S)-1-(N-t-butoxycarbonyl)aminomethyl-2-(triphenylmethoxy)methylcyclopropane (1449741-33-6) → ((1R,2S)-2-Hydroxymethyl-cyclopropylmethyl)-carbamic acid tert-butyl ester (153861-59-7,167255-48-3,167255-49-4)

Guidance literature:

With water; acetic acid; at 20 ℃; for 11h;

DOI:10.1016/j.bmc.2013.06.063

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → ((1R,2S)-2-Hydroxymethyl-cyclopropylmethyl)-carbamic acid tert-butyl ester (153861-59-7,167255-48-3,167255-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrahydrofuran / Ambient temperature

2: hydrogen / palladium on activated charcoal / methanol / 3 h / Ambient temperature

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jo00080a017

upstream raw materials:

(1R,2S)-2-<(Benzyloxy)methyl>-1-<methyl>cyclopropane

di-tert-butyl dicarbonate

C-((1R,2S)-2-Benzyloxymethyl-cyclopropyl)-methylamine

(1R,2S)-2-<(Benzyloxy)methyl>-1-(hydroxymethyl)cyclopropane