(R)-2,2-Dimethyl-N-(1-phenyl-2-(piperidin-1-yl)ethyl)propan-1-amine

Base Information

Chemical Name:(R)-2,2-Dimethyl-N-(1-phenyl-2-(piperidin-1-yl)ethyl)propan-1-amine
CAS No.:153837-28-6
Molecular Formula:C₁₈H₃₀N₂
Molecular Weight:274.45
Hs Code.:2933399090
DSSTox Substance ID:DTXSID80428824
Nikkaji Number:J781.930G
Mol file:153837-28-6.mol

Synonyms:153837-28-6;(R)-2,2-Dimethyl-N-(1-phenyl-2-(piperidin-1-yl)ethyl)propan-1-amine;(R)-(-)-N-Neopentyl-1-phenyl-2-(1-piperidinyl)ethylamine;2,2-dimethyl-N-[(1R)-1-phenyl-2-piperidin-1-ylethyl]propan-1-amine;ST081399;DTXSID80428824;RUWFXOINQANLGF-KRWDZBQOSA-N;(R)-(-)-N-NEOPENTYL-1-PHENYL-2-(1-PIPERIDINO)ETHYLAMINE;MFCD06795639;AKOS024285107;CS-0447216;(1R)-N-(2,2-Dimethylpropyl)-1-phenyl-2-piperidinoethanamine;(2,2-DIMETHYLPROPYL)[(1R)-1-PHENYL-2-(PIPERIDIN-1-YL)ETHYL]AMINE

Suppliers and Price of (R)-2,2-Dimethyl-N-(1-phenyl-2-(piperidin-1-yl)ethyl)propan-1-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(R)-(-)-N-NEOPENTYL-1-PHENYL-2-(1-PIPERIDINO)ETHYLAMINE 95.00%
1G
$ 897.44

American Custom Chemicals Corporation
(R)-(-)-N-NEOPENTYL-1-PHENYL-2-(1-PIPERIDINO)ETHYLAMINE 95.00%
250MG
$ 656.10

American Custom Chemicals Corporation
(R)-(-)-N-NEOPENTYL-1-PHENYL-2-(1-PIPERIDINO)ETHYLAMINE 95.00%
5G
$ 2116.25

Alfa Aesar
(R)-(-)-N-Neopentyl-1-phenyl-2-(1-piperidinyl)ethylamine, 97%
5g
$ 1134.00

Alfa Aesar
(R)-(-)-N-Neopentyl-1-phenyl-2-(1-piperidinyl)ethylamine, 97%
1g
$ 260.00

Alfa Aesar
(R)-(-)-N-Neopentyl-1-phenyl-2-(1-piperidinyl)ethylamine, 97%
250mg
$ 99.60

Total 8 raw suppliers

Chemical Property of (R)-2,2-Dimethyl-N-(1-phenyl-2-(piperidin-1-yl)ethyl)propan-1-amine

Chemical Property:

Vapor Pressure:1.35E-05mmHg at 25°C
Melting Point:36-40°C
Refractive Index:1.517
Boiling Point:367.7°Cat760mmHg
PKA:9.55±0.48(Predicted)
Flash Point:113.6°C
PSA：15.27000
Density:0.953g/cm³
LogP:4.17810
Sensitive.:Air Sensitive
Water Solubility.:Insoluble in water.
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:274.240898965
Heavy Atom Count:20
Complexity:257

Purity/Quality:

99% ^*data from raw suppliers

(R)-(-)-N-NEOPENTYL-1-PHENYL-2-(1-PIPERIDINO)ETHYLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s): R34:Causes burns.;
Hazard Codes:R34:Causes burns.;
Statements: 34
Safety Statements: 26-36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)CNC(CN1CCCCC1)C2=CC=CC=C2
Isomeric SMILES:CC(C)(C)CN[C@@H](CN1CCCCC1)C2=CC=CC=C2
Uses (R)-(-)-N-Neopentyl-1-phenyl-2-(1-piperidinyl)ethylamine is a pharmaceutical intermediate.

Technology Process of (R)-2,2-Dimethyl-N-(1-phenyl-2-(piperidin-1-yl)ethyl)propan-1-amine

There total 9 articles about (R)-2,2-Dimethyl-N-(1-phenyl-2-(piperidin-1-yl)ethyl)propan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 5813-64-9
2.2-dimethylpropylamine

: 40116-77-6
(R)-1-phenyl-2-(1-piperidinyl)ethanol

: 153837-28-6
(2,2-Me₂-propyl)-((R)-1-phenyl-2-piperidin-1-yl-ethyl)-amine

Guidance literature:: (R)-1-phenyl-2-(1-piperidinyl)ethanol; With methanesulfonyl chloride; triethylamine; In diethyl ether; for 0.5h;

2.2-dimethylpropylamine; With water; triethylamine; In diethyl ether; at 20 ℃; for 16h;
DOI:10.1055/s-2001-12768

Reference yield:

: 110-89-4
piperidine

: 153837-28-6
(2,2-Me₂-propyl)-((R)-1-phenyl-2-piperidin-1-yl-ethyl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / Heating

2.1: Et₃N; MsCl / diethyl ether / 0.5 h

2.2: 85 percent / Et₃N; H₂O / diethyl ether / 16 h / 20 °C

With methanesulfonyl chloride; triethylamine; In diethyl ether; ethanol;
DOI:10.1055/s-2001-12768

Reference yield:

: 20780-53-4
(R)-Styrene oxide

: 153837-28-6
(2,2-Me₂-propyl)-((R)-1-phenyl-2-piperidin-1-yl-ethyl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / Heating

2.1: Et₃N; MsCl / diethyl ether / 0.5 h

2.2: 85 percent / Et₃N; H₂O / diethyl ether / 16 h / 20 °C

With methanesulfonyl chloride; triethylamine; In diethyl ether; ethanol;
DOI:10.1055/s-2001-12768