2-[2-[8-benzyloxy-7-methoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]-4,5-dimethoxyphenyl]-ethanol

Base Information

Chemical Name:2-[2-[8-benzyloxy-7-methoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]-4,5-dimethoxyphenyl]-ethanol
CAS No.:290309-72-7
Molecular Formula:C₃₄H₃₇NO₇S
Molecular Weight:603.736
Hs Code.:

Synonyms:2-[2-[8-benzyloxy-7-methoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]-4,5-dimethoxyphenyl]-ethanol

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Chemical Property of 2-[2-[8-benzyloxy-7-methoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]-4,5-dimethoxyphenyl]-ethanol

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Technology Process of 2-[2-[8-benzyloxy-7-methoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]-4,5-dimethoxyphenyl]-ethanol

There total 5 articles about 2-[2-[8-benzyloxy-7-methoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]-4,5-dimethoxyphenyl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 290309-71-6
{2-[8-benzyloxy-7-methoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-4,5-dimethoxy-phenyl}-acetaldehyde

: 290309-72-7
2-[2-[8-benzyloxy-7-methoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]-4,5-dimethoxyphenyl]-ethanol

Guidance literature:: With sodium tetrahydroborate; In methanol; diethyl ether;

Reference yield:

: 93-15-2
1,2-dimethoxy-4-(2-propenyl)benzene

: 290309-72-7
2-[2-[8-benzyloxy-7-methoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]-4,5-dimethoxyphenyl]-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / BF₃*Et₂O / CH₂Cl₂ / 0.75 h / -78 - -30 °C

2: 77 percent / OsO₄; aq. KIO₄ / 2-methyl-propan-2-ol; tetrahydrofuran / 20 °C

3: 92 percent / NaBH₄ / methanol; diethyl ether / 0.25 h / 0 °C

With sodium tetrahydroborate; osmium(VIII) oxide; potassium metaperiodate; boron trifluoride diethyl etherate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; tert-butyl alcohol;
DOI:10.1139/v00-120

Reference yield:

: 290309-56-7
3-(2-allyl-4,5-dimethoxyphenyl)-8-benzyloxy-7-methoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroisoquinoline

: 290309-72-7
2-[2-[8-benzyloxy-7-methoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]-4,5-dimethoxyphenyl]-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / OsO₄; aq. KIO₄ / 2-methyl-propan-2-ol; tetrahydrofuran / 20 °C

2: 92 percent / NaBH₄ / methanol; diethyl ether / 0.25 h / 0 °C

With sodium tetrahydroborate; osmium(VIII) oxide; potassium metaperiodate; In tetrahydrofuran; methanol; diethyl ether; tert-butyl alcohol;
DOI:10.1139/v00-120