Benzoic acid (3R,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester

Base Information

Chemical Name:Benzoic acid (3R,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester
CAS No.:478158-92-8
Molecular Formula:C₂₈H₃₂O₃SSi
Molecular Weight:476.712
Hs Code.:

Synonyms:Benzoic acid (3R,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzoic acid (3R,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester

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Technology Process of Benzoic acid (3R,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester

There total 1 articles about Benzoic acid (3R,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 65-85-0,8013-63-6
benzoic acid

: 478158-91-7
(3S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-ol

: 478158-92-8
Benzoic acid (3R,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 50 ℃; for 15h;
DOI:10.1016/S0960-894X(02)00394-3

Reference yield: 65.0%

: 478158-92-8
Benzoic acid (3R,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester

: 478158-93-9
(3R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-ol

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 15h;
DOI:10.1016/S0960-894X(02)00394-3

Reference yield:

: 478158-92-8
Benzoic acid (3R,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester

: 1-[3-azido-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / NH₃ / methanol / 15 h / 20 °C

2: 87 percent / PPh₃; DEAD; diphenylphosphoryl azide / tetrahydrofuran / 1 h / 0 °C

3: 95 percent / mCPBA / CH₂Cl₂ / 2 h / -78 °C

4: 87 percent / 15 h / 100 °C

5: 75 percent / TMSOTf / 1,2-dichloro-ethane / 12 h / 20 °C

With trimethylsilyl trifluoromethanesulfonate; diphenylphosphoranyl azide; ammonia; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; 2: Mitsunobu reaction;
DOI:10.1016/S0960-894X(02)00394-3