1-cyclohexyl-5,6-dihydro-4-(4-morpholinylcarbonyl)-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-7-carboxylic acid, methyl ester

Base Information

Chemical Name:1-cyclohexyl-5,6-dihydro-4-(4-morpholinylcarbonyl)-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-7-carboxylic acid, methyl ester
CAS No.:1055320-91-6
Molecular Formula:C₃₀H₃₄N₂O₄
Molecular Weight:486.611
Hs Code.:

Synonyms:1-cyclohexyl-5,6-dihydro-4-(4-morpholinylcarbonyl)-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-7-carboxylic acid, methyl ester

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Chemical Property of 1-cyclohexyl-5,6-dihydro-4-(4-morpholinylcarbonyl)-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-7-carboxylic acid, methyl ester

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Technology Process of 1-cyclohexyl-5,6-dihydro-4-(4-morpholinylcarbonyl)-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-7-carboxylic acid, methyl ester

There total 12 articles about 1-cyclohexyl-5,6-dihydro-4-(4-morpholinylcarbonyl)-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-7-carboxylic acid, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 4H-pyrrolo[3,2,1-ij]quinoline-4,7-dicarboxylic acid,1-cyclohexyl-5,6-dihydro-2-phenyl-, 7-methyl ester

: 1055320-91-6
1-cyclohexyl-5,6-dihydro-4-(4-morpholinylcarbonyl)-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-7-carboxylic acid, methyl ester

Guidance literature:: In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 1055320-72-3
7-chloro-1H-indole-6-carboxylic acid

: 1055320-91-6
1-cyclohexyl-5,6-dihydro-4-(4-morpholinylcarbonyl)-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-7-carboxylic acid, methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium methylate / methanol / 23 h / 20 - 60 °C / Heating / reflux

1.2: 20 °C

2.1: hydrogen / 20% Pd(OH)2 on carbon / tetrahydrofuran; methanol / 27 h / 20 °C

3.1: methanol; hexane; benzene / 2.25 h / 0 - 20 °C

3.2: 0.25 h

4.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 2 h / 20 °C

5.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 20 - 60 °C

6.1: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 20 - 120 °C

7.1: sodium hydride / dimethyl sulfoxide / 0.17 h / 20 °C

7.2: 2.33 h / 20 - 200 °C / Microwave irradiation

8.1: methanol; hexane; benzene / 1.67 h / 20 °C

9.1: potassium trimethylsilonate / tetrahydrofuran / 17 h / 20 °C

10.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

11.1: dichloromethane / 1.5 h / 20 °C

With oxalyl dichloride; potassium trimethylsilonate; hydrogen; sodium methylate; pyridinium hydrobromide perbromide; sodium hydride; sodium carbonate; cesium fluoride; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; 20% Pd(OH)2 on carbon; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; toluene; benzene;

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1055320-91-6
1-cyclohexyl-5,6-dihydro-4-(4-morpholinylcarbonyl)-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-7-carboxylic acid, methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium methylate / methanol / 23 h / 20 - 60 °C / Heating / reflux

1.2: 20 °C

2.1: hydrogen / 20% Pd(OH)2 on carbon / tetrahydrofuran; methanol / 27 h / 20 °C

3.1: methanol; hexane; benzene / 2.25 h / 0 - 20 °C

3.2: 0.25 h

4.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 2 h / 20 °C

5.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 20 - 60 °C

6.1: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 20 - 120 °C

7.1: sodium hydride / dimethyl sulfoxide / 0.17 h / 20 °C

7.2: 2.33 h / 20 - 200 °C / Microwave irradiation

8.1: methanol; hexane; benzene / 1.67 h / 20 °C

9.1: potassium trimethylsilonate / tetrahydrofuran / 17 h / 20 °C

10.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

11.1: dichloromethane / 1.5 h / 20 °C

With oxalyl dichloride; potassium trimethylsilonate; hydrogen; sodium methylate; pyridinium hydrobromide perbromide; sodium hydride; sodium carbonate; cesium fluoride; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; 20% Pd(OH)2 on carbon; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; toluene; benzene;