H-alpha-Me-D-Phe(3-I)-OH

Base Information

Chemical Name:H-alpha-Me-D-Phe(3-I)-OH
CAS No.:457652-83-4
Molecular Formula:C₁₀H₁₂INO₂
Molecular Weight:305.115
Hs Code.:
DSSTox Substance ID:DTXSID10438693
Nikkaji Number:J1.895.840F
Mol file:457652-83-4.mol

Synonyms:H-alpha-Me-D-Phe(3-I)-OH;457652-83-4;(2R)-2-amino-3-(3-iodophenyl)-2-methylpropanoic acid;(R)-alpha-Methyl-3-iodophenylalanine (>98%, >98%ee);SCHEMBL5182245;H-alpha-Me-L-Phe(3-I)-OH;DTXSID10438693;RCYLCZQGMUWCBV-SNVBAGLBSA-N;3-Iodo-alpha-methyl-D-phenylalanine;AKOS030213015;A897908;(R)-2-Amino-2-methyl-3-(3-iodophenyl)propanoic acid;(S)-Alpha-methyl-3-iodophenylalanine(>98%,>98%ee)

Suppliers and Price of H-alpha-Me-D-Phe(3-I)-OH

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemPep
α-Me-D-Phe(3-I)-OH?H2O
1g
$ 650.00

Total 6 raw suppliers

Chemical Property of H-alpha-Me-D-Phe(3-I)-OH

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.637
Boiling Point:390.271°C at 760 mmHg
Flash Point:189.829°C
PSA：63.32000
Density:1.737g/cm³
LogP:2.33600
XLogP3:-0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:304.99128
Heavy Atom Count:14
Complexity:222

Purity/Quality:

97% ^*data from raw suppliers

α-Me-D-Phe(3-I)-OH?H2O ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(CC1=CC(=CC=C1)I)(C(=O)O)N
Isomeric SMILES:C[C@@](CC1=CC(=CC=C1)I)(C(=O)O)N

Technology Process of H-alpha-Me-D-Phe(3-I)-OH

There total 5 articles about H-alpha-Me-D-Phe(3-I)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: benzyl (2R,4S)-4-(3-iodobenzyl)-4-methyl-5-oxo-2-phenyl-1,3-oxazolidine-3-carboxylate

: 457652-83-4
(S)-2-amino-3-(3-iodophenyl)-2-methylpropanoic acid

Guidance literature:: With potassium trimethylsilonate; In tetrahydrofuran; at 75 ℃; for 2.5h;
DOI:10.1039/b212454h

Reference yield: 95.0%

: benzyl (2S,4R)-4-(3-iodobenzyl)-4-methyl-5-oxo-2-phenyl-1,3-oxazolidine-3-carboxylate

: 457652-83-4
(R)-3-iodo-α-methylphenylalanine

Guidance literature:: With potassium trimethylsilonate; In tetrahydrofuran; at 75 ℃; for 2.5h;
DOI:10.1039/b212454h

Reference yield:

: 49617-83-6
m-Iodobenzyl bromide

: 457652-83-4
(S)-2-amino-3-(3-iodophenyl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / LiN(TMS)2 / tetrahydrofuran / 4 h / -30 - 20 °C

2: 98 percent / KOSiMe₃ / tetrahydrofuran / 2.5 h / 75 °C

With potassium trimethylsilonate; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1039/b212454h