1-acetyl-4-<2-(6-(4-chlorobutoxy))naphthyl>-4-(3-bromo-4-hydroxy-5-methoxyphenyl)piperidine

Base Information

Chemical Name:1-acetyl-4-<2-(6-(4-chlorobutoxy))naphthyl>-4-(3-bromo-4-hydroxy-5-methoxyphenyl)piperidine
CAS No.:162968-06-1
Molecular Formula:C₂₈H₃₁BrClNO₄
Molecular Weight:560.915
Hs Code.:

Synonyms:1-acetyl-4-<2-(6-(4-chlorobutoxy))naphthyl>-4-(3-bromo-4-hydroxy-5-methoxyphenyl)piperidine

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Chemical Property of 1-acetyl-4-<2-(6-(4-chlorobutoxy))naphthyl>-4-(3-bromo-4-hydroxy-5-methoxyphenyl)piperidine

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Technology Process of 1-acetyl-4-<2-(6-(4-chlorobutoxy))naphthyl>-4-(3-bromo-4-hydroxy-5-methoxyphenyl)piperidine

There total 6 articles about 1-acetyl-4-<2-(6-(4-chlorobutoxy))naphthyl>-4-(3-bromo-4-hydroxy-5-methoxyphenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 162968-05-0
1-acetyl-4-{2-[6-(4-chlorobutoxy)]naphthyl}-4-(4-hydroxy-3-methoxyphenyl)piperidine

: 162968-06-1
1-acetyl-4-<2-(6-(4-chlorobutoxy))naphthyl>-4-(3-bromo-4-hydroxy-5-methoxyphenyl)piperidine

Guidance literature:: With N-Bromosuccinimide; sodium hydride; In methanol; dichloromethane; at -50 ℃; for 8h;
DOI:10.1016/0040-4020(94)00905-A

Reference yield:

: 32161-06-1
1-acetyl-4-piperidinone

: 162968-06-1
1-acetyl-4-<2-(6-(4-chlorobutoxy))naphthyl>-4-(3-bromo-4-hydroxy-5-methoxyphenyl)piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: 1) Mg, I₂ / 1) THF, 10 min, reflux then 20 deg C, 1 h, 2) THF, 20 deg C, 2 h

2: BBr₃ / CH₂Cl₂ / 2.5 h / Heating

3: 65 percent / NaH / dimethylformamide / 12 h / 20 °C

4: 90 percent / BF₃*Et₂O / CH₂Cl₂ / 216 h / 20 °C

5: 59 percent / NaH (60percent in oil), NBS / CH₂Cl₂; methanol / 8 h / -50 °C

With N-Bromosuccinimide; boron trifluoride diethyl etherate; iodine; boron tribromide; sodium hydride; magnesium; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(94)00905-A

Reference yield:

: 66217-19-4
2-ethoxy-6-bromo-naphthalene

: 162968-06-1
1-acetyl-4-<2-(6-(4-chlorobutoxy))naphthyl>-4-(3-bromo-4-hydroxy-5-methoxyphenyl)piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: 1) Mg, I₂ / 1) THF, 10 min, reflux then 20 deg C, 1 h, 2) THF, 20 deg C, 2 h

2: BBr₃ / CH₂Cl₂ / 2.5 h / Heating

3: 65 percent / NaH / dimethylformamide / 12 h / 20 °C

4: 90 percent / BF₃*Et₂O / CH₂Cl₂ / 216 h / 20 °C

5: 59 percent / NaH (60percent in oil), NBS / CH₂Cl₂; methanol / 8 h / -50 °C

With N-Bromosuccinimide; boron trifluoride diethyl etherate; iodine; boron tribromide; sodium hydride; magnesium; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(94)00905-A