1-((2R,4S,5R)-4-Azido-5-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Name:1-((2R,4S,5R)-4-Azido-5-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:136505-31-2
Molecular Formula:C₃₁H₃₁N₅O₅
Molecular Weight:553.618
Hs Code.:

Synonyms:1-((2R,4S,5R)-4-Azido-5-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-((2R,4S,5R)-4-Azido-5-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-((2R,4S,5R)-4-Azido-5-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

There total 7 articles about 1-((2R,4S,5R)-4-Azido-5-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 136505-30-1
Methanesulfonic acid (2R,3R,5R)-2-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

: 136505-31-2
1-((2R,4S,5R)-4-Azido-5-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; for 2h; Heating;
DOI:10.1016/S0040-4039(00)92706-0

Reference yield:

: 136505-25-4
1-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(2-hydroxy-ethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 136505-31-2
1-((2R,4S,5R)-4-Azido-5-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / pyridine / 2 h / Ambient temperature

2: 67 percent / pyridine / 1.5 h / Ambient temperature

3: 50 percent / Bu₃SnH, AIBN / toluene / 2 h / Heating

4: 91 percent / pyridine / 2 h / Ambient temperature

5: 74 percent / NaN₃ / dimethylformamide / 2 h / Heating

With pyridine; sodium azide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)92706-0

Reference yield:

: 7333-32-6,136505-40-3,136523-39-2
Acetic acid (2R,3S,4R)-4,5-diacetoxy-2-(2-acetoxy-ethyl)-tetrahydro-furan-3-yl ester

: 136505-31-2
1-((2R,4S,5R)-4-Azido-5-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethyl}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 7 steps

1: TMSOTf / acetonitrile / 4 h / Ambient temperature

2: NaOMe / methanol / 1 h / Ambient temperature

3: 96 percent / pyridine / 2 h / Ambient temperature

4: 67 percent / pyridine / 1.5 h / Ambient temperature

5: 50 percent / Bu₃SnH, AIBN / toluene / 2 h / Heating

6: 91 percent / pyridine / 2 h / Ambient temperature

7: 74 percent / NaN₃ / dimethylformamide / 2 h / Heating

With pyridine; sodium azide; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; tri-n-butyl-tin hydride; sodium methylate; In methanol; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0040-4039(00)92706-0