3-Flavanol, cis-

Base Information

Chemical Name:3-Flavanol, cis-
CAS No.:55568-98-4
Molecular Formula:C₁₅H₁₄O₂
Molecular Weight:226.275
Hs Code.:
UNII:4XZ3RL53CZ,C0D8VIF15V
Nikkaji Number:J1.909.877J

Synonyms:3-Flavanol, cis-;2,3-cis-Flavan-3-ol;3-Flavanol, cis-(-)-;4XZ3RL53CZ;C0D8VIF15V;3-Flavanol, cis-(+/-)-;116002-72-3;55568-98-4;2H-1-Benzopyran-3-ol, 3,4-dihydro-2-phenyl-, cis-;2H-1-Benzopyran-3-ol, 3,4-dihydro-2-phenyl-, (2R,3R)-;2H-1-Benzopyran-3-ol, 3,4-dihydro-2-phenyl-, (2R-cis)-;UNII-4XZ3RL53CZ;UNII-C0D8VIF15V;SCHEMBL460037

Suppliers and Price of 3-Flavanol, cis-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 3-Flavanol, cis-

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:226.099379685
Heavy Atom Count:17
Complexity:247

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(C(OC2=CC=CC=C21)C3=CC=CC=C3)O
Isomeric SMILES:C1[C@H]([C@H](OC2=CC=CC=C21)C3=CC=CC=C3)O

Technology Process of 3-Flavanol, cis-

There total 27 articles about 3-Flavanol, cis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 299412-44-5
(2R,3R)-cis-3-[(tert-butyldimethylsilyl)oxy]flavan

: 55568-98-4
(2R,3S)-2-phenylchroman-3-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jo000485+

Reference yield:

: (S)-2-phenyl-2H-chromene

: 55568-98-4
(2R,3S)-2-phenylchroman-3-ol

: 55568-96-2
(2R,3S)-2-phenylchroman-3-ol

Guidance literature:: (S)-2-phenyl-2H-chromene; With borane-THF;

With dihydrogen peroxide; sodium hydroxide; Overall yield = 63 %;
DOI:10.1039/c4sc00423j

Reference yield:

: 87292-49-7
5,7,3',4'-tetra-O-benzylepicatechin

: 55568-98-4
(2R,3S)-2-phenylchroman-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 98 percent / imidazole / dimethylformamide / 19.5 h / 20 °C

2.1: 109 mg / H₂ / Pd(OH)2/C / ethyl acetate / 1 h / 20 °C / 750.08 Torr

3.1: NaH / 0.17 h / 0 °C

3.2: 73.6 mg / 3 h / cooling

4.1: 51 percent / H₂ / Pd(OH)2/C / methanol; ethyl acetate / 41.5 h / 20 °C / 750.08 Torr

5.1: 97 percent / Bu₄NF / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; palladium dihydroxide; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; 1.1: silylation / 2.1: Hydrogenolysis / 3.1: Hydrogenolysis / 3.2: Etherification / 4.1: Hydrogenolysis / 5.1: desilylation;
DOI:10.1021/jo000485+